Use of organotypic coculture to study keloid biology
Butler PD, Ly DP, Longaker MT, Yang GP. Use of organotypic coculture to study keloid biology. The American Journal Of Surgery 2008, 195: 144-148. PMID: 18070722, PMCID: PMC2245861, DOI: 10.1016/j.amjsurg.2007.10.003.Peer-Reviewed Original ResearchConceptsNormal human keratinocytesAnimal modelsKeloid formationOrganotypic skinKeloid biologyDermal contracturesDefinitive therapyFetal calf serumOrganotypic skin modelsCollagen depositionDermal thicknessMuscle actinOrganotypic skin culturesSkin culturesCollagen stainingPathologic scarsOrganotypic coculturesCollagen productionHuman keratinocytesSkinContractureCalf serumDermal layerDermal structuresEagle's medium