2022
A phase II study of sapanisertib (TAK-228) a mTORC1/2 inhibitor in rapalog-resistant advanced pancreatic neuroendocrine tumors (PNET): ECOG-ACRIN EA2161
Rajdev L, Lee JW, Libutti SK, Benson AB, Fisher GA, Kunz PL, Hendifar AE, Catalano P, O’Dwyer P. A phase II study of sapanisertib (TAK-228) a mTORC1/2 inhibitor in rapalog-resistant advanced pancreatic neuroendocrine tumors (PNET): ECOG-ACRIN EA2161. Investigational New Drugs 2022, 40: 1306-1314. PMID: 36264382, PMCID: PMC9795724, DOI: 10.1007/s10637-022-01311-w.Peer-Reviewed Original ResearchMeSH KeywordsHumansMechanistic Target of Rapamycin Complex 1MTOR InhibitorsNeuroectodermal Tumors, PrimitiveNeuroendocrine TumorsPancreatic NeoplasmsProtein Kinase InhibitorsSirolimusConceptsPancreatic neuroendocrine tumorsNeuroendocrine tumorsTreatment-related grade 3 adverse eventsGrade 3 adverse eventsAdvanced pancreatic neuroendocrine tumorsTwo-stage phase II trialObjective tumor responsePhase II studyPhase II trialContinuous dosing scheduleStage 1Lack of responseEligible patientsMedian OSMedian PFSII trialAdverse eventsII studyObjective responseDosing schedulesTumor responseClinical activityPatientsMTOR pathwayMTORC1/2 inhibitors
2012
Neoadjuvant imatinib for borderline resectable GIST.
Koontz MZ, Visser BM, Kunz PL. Neoadjuvant imatinib for borderline resectable GIST. Journal Of The National Comprehensive Cancer Network 2012, 10: 1477-82; quiz 1482. PMID: 23221786, DOI: 10.6004/jnccn.2012.0154.Peer-Reviewed Original ResearchMeSH KeywordsAdultBenzamidesFemaleGastrointestinal Stromal TumorsHumansImatinib MesylateNeoadjuvant TherapyPiperazinesProtein Kinase InhibitorsPyrimidinesRadiographyTreatment OutcomeConceptsGastrointestinal stromal tumorsNeoadjuvant imatinibNeoadjuvant tyrosine kinase-inhibitor therapyResectable gastrointestinal stromal tumorsTyrosine kinase inhibitor therapyBorderline resectable tumorsCommon bile ductSuperior mesenteric veinKinase inhibitor therapyOptimal imaging modalityViable treatment strategySpindle cell neoplasmResectable tumorsRed blood cellsUpper endoscopyBlack stoolInhibitor therapyBile ductMedical oncologyStromal tumorsEmergency departmentCase reportMesenteric veinCell neoplasmsTreatment strategies