2015
DNA-repair defects in pancreatic neuroendocrine tumors and potential clinical applications
Liu IH, Ford JM, Kunz PL. DNA-repair defects in pancreatic neuroendocrine tumors and potential clinical applications. Cancer Treatment Reviews 2015, 44: 1-9. PMID: 26924193, DOI: 10.1016/j.ctrv.2015.11.006.Peer-Reviewed Original ResearchConceptsDNA repair pathwaysDNA repair defectsRepair pathwaysRepair genesRelevant DNA repair pathwaysPromoter hypermethylationDNA repair gene MGMTDNA repair processesDNA repair genesMMR genesTumor samplesDNA repairGene MGMTSpecific genesLoss of expressionUnderexpressed genesRepair defectsGenetic landscapeGenesMLH1 MMR geneDNA mismatch repair genesRepair mechanismsMGMT geneMismatch repair genesPTEN
2010
Expression of p16INK4A but not hypoxia markers or poly adenosine diphosphate‐ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinoma
Chang DT, Chapman CH, Norton JA, Visser B, Fisher GA, Kunz P, Ford JM, Koong AC, Pai RK. Expression of p16INK4A but not hypoxia markers or poly adenosine diphosphate‐ribose polymerase is associated with improved survival in patients with pancreatic adenocarcinoma. Cancer 2010, 116: 5179-5187. PMID: 20665497, DOI: 10.1002/cncr.25481.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAntigens, NeoplasmBiomarkers, TumorCarbonic Anhydrase IXCarbonic AnhydrasesCell HypoxiaCyclin-Dependent Kinase Inhibitor p16Disease-Free SurvivalFemaleHumansImmunohistochemistryMaleMiddle AgedPancreatic NeoplasmsPoly(ADP-ribose) PolymerasesPrognosisProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsTetrahydrofolate DehydrogenaseTissue Array AnalysisConceptsProgression-free survivalOverall survivalPoly adenosine diphosphate-ribose polymerasePancreatic adenocarcinomaImproved OSImmunohistochemical expressionHypoxia markersImproved overall survivalCyclin-dependent kinase inhibitor 2AExpression of p16INK4aCarbonic anhydrase IXAdjuvant chemotherapyCurative resectionMedian survivalImproved survivalMargin statusClinical outcomesPrimary tumorPancreatic cancerUnivariate analysisSurgical specimensImmunohistochemical stainingTissue microarrayPositive stainingPatients