2023
Age- and sex-based differences in the genomic profiles of patients with gastrointestinal (GI) and pancreatic neuroendocrine neoplasms (NENs).
Liu L, Li S, Gandhi N, Farrell A, Lou E, Soares H, Nazha B, Swensen J, Oberley M, Nabhan C, Abraham J, Korn W, Kunz P, Vijayvergia N. Age- and sex-based differences in the genomic profiles of patients with gastrointestinal (GI) and pancreatic neuroendocrine neoplasms (NENs). Journal Of Clinical Oncology 2023, 41: 655-655. DOI: 10.1200/jco.2023.41.4_suppl.655.Peer-Reviewed Original ResearchNeuroendocrine neoplasmsPancreatic neuroendocrine neoplasmsP-NENsGI-NENGI-NENsImmune profileKRAS mutationsImmune checkpoint gene expressionHigh tumor mutation burdenCaris Life SciencesDMMR/MSIDistinct immune profilesTumor mutation burdenYears of ageMechanisms of ageWhole-exome sequencingMann-Whitney USex-based differencesSite of originDistinct molecular profilesICGs expressionAge-associated effectsOverall survivalPatient demographicsImmune landscape
2022
Exploratory genomic analysis of high-grade neuroendocrine neoplasms across diverse primary sites.
Sun TY, Zhao L, Van Hummelen P, Martin B, Hornbacker K, Lee H, Xia LC, Padda SK, Ji HP, Kunz P. Exploratory genomic analysis of high-grade neuroendocrine neoplasms across diverse primary sites. Endocrine Related Cancer 2022, 29: 665-679. PMID: 36165930, PMCID: PMC10043760, DOI: 10.1530/erc-22-0015.Peer-Reviewed Original ResearchConceptsHigh-grade neuroendocrine neoplasmsDiverse primary sitesG3 NENNeuroendocrine neoplasmsPrimary siteHigh tumor mutation burdenExploratory genomic analysisTumor mutation burdenPoor survival outcomesMutations/MbDifferent primary sitesOrgan of originRare cancer typesSurvival outcomesWorse prognosisRare tumorCell cycling pathwaysMutation burdenTherapeutic implicationsClinical standpointSomatic copy number alterationsCopy number alterationsCancer typesNeoplasmsUpregulation of oncogenes
2020
Comprehensive genomic sequencing of high-grade neuroendocrine neoplasms.
Sun T, Van Hummelen P, Martin B, Xia C, Lee H, Zhao L, Hornbacker K, Ji H, Kunz P. Comprehensive genomic sequencing of high-grade neuroendocrine neoplasms. Journal Of Clinical Oncology 2020, 38: 624-624. DOI: 10.1200/jco.2020.38.4_suppl.624.Peer-Reviewed Original Research