DNA-repair defects in pancreatic neuroendocrine tumors and potential clinical applications
Liu IH, Ford JM, Kunz PL. DNA-repair defects in pancreatic neuroendocrine tumors and potential clinical applications. Cancer Treatment Reviews 2015, 44: 1-9. PMID: 26924193, DOI: 10.1016/j.ctrv.2015.11.006.Peer-Reviewed Original ResearchConceptsDNA repair pathwaysDNA repair defectsRepair pathwaysRepair genesRelevant DNA repair pathwaysPromoter hypermethylationDNA repair gene MGMTDNA repair processesDNA repair genesMMR genesTumor samplesDNA repairGene MGMTSpecific genesLoss of expressionUnderexpressed genesRepair defectsGenetic landscapeGenesMLH1 MMR geneDNA mismatch repair genesRepair mechanismsMGMT geneMismatch repair genesPTEN