2022
Exploratory genomic analysis of high-grade neuroendocrine neoplasms across diverse primary sites.
Sun TY, Zhao L, Van Hummelen P, Martin B, Hornbacker K, Lee H, Xia LC, Padda SK, Ji HP, Kunz P. Exploratory genomic analysis of high-grade neuroendocrine neoplasms across diverse primary sites. Endocrine Related Cancer 2022, 29: 665-679. PMID: 36165930, PMCID: PMC10043760, DOI: 10.1530/erc-22-0015.Peer-Reviewed Original ResearchConceptsHigh-grade neuroendocrine neoplasmsDiverse primary sitesG3 NENNeuroendocrine neoplasmsPrimary siteHigh tumor mutation burdenExploratory genomic analysisTumor mutation burdenPoor survival outcomesMutations/MbDifferent primary sitesOrgan of originRare cancer typesSurvival outcomesWorse prognosisRare tumorCell cycling pathwaysMutation burdenTherapeutic implicationsClinical standpointSomatic copy number alterationsCopy number alterationsCancer typesNeoplasmsUpregulation of oncogenes
2021
Making Sense of a Complex Disease: A Practical Approach to Managing Neuroendocrine Tumors
Zhang JY, Kunz PL. Making Sense of a Complex Disease: A Practical Approach to Managing Neuroendocrine Tumors. JCO Oncology Practice 2021, 18: 258-264. PMID: 34652954, DOI: 10.1200/op.21.00240.Peer-Reviewed Original ResearchConceptsNeuroendocrine tumorsFunctional statusPrimary sitePrevalence of NETsMetastatic neuroendocrine tumorsExtent of diseaseOngoing clinical trialsSomatostatin receptor statusIndividualized treatment planHeterogeneous clinical entityPace of diseaseConsideration of patientsPerformance statusSystemic therapyReceptor statusTumor characteristicsClinical entityTherapeutic optionsPathologic classificationClinical trialsTherapeutic decisionsDiagnostic modalitiesTreatment planDiseasePatients
2013
Diagnostic discrepancies between second-opinion and referring pathology reports of neuroendocrine tumors.
Lin H, Longacre T, Khandelwal V, Balise R, Kunz P. Diagnostic discrepancies between second-opinion and referring pathology reports of neuroendocrine tumors. Journal Of Clinical Oncology 2013, 31: 154-154. DOI: 10.1200/jco.2013.31.4_suppl.154.Peer-Reviewed Original ResearchNeuroendocrine tumorsPathology reportsMitotic indexDiagnosis of NETsHistologic classification schemeStanford University HospitalNET casesMajority of casesRare malignancyUniversity HospitalGastrointestinal tractNET diagnosisPathology guidelinesPrimary siteHistologic descriptionDiagnostic discrepanciesSmall intestineClinical diagnosisMajor discrepanciesNeuroendocrine cellsKi67DiagnosisMost reportsPathology expertsTumors