2022
A phase II study of sapanisertib (TAK-228) a mTORC1/2 inhibitor in rapalog-resistant advanced pancreatic neuroendocrine tumors (PNET): ECOG-ACRIN EA2161
Rajdev L, Lee JW, Libutti SK, Benson AB, Fisher GA, Kunz PL, Hendifar AE, Catalano P, O’Dwyer P. A phase II study of sapanisertib (TAK-228) a mTORC1/2 inhibitor in rapalog-resistant advanced pancreatic neuroendocrine tumors (PNET): ECOG-ACRIN EA2161. Investigational New Drugs 2022, 40: 1306-1314. PMID: 36264382, PMCID: PMC9795724, DOI: 10.1007/s10637-022-01311-w.Peer-Reviewed Original ResearchConceptsPancreatic neuroendocrine tumorsNeuroendocrine tumorsTreatment-related grade 3 adverse eventsGrade 3 adverse eventsAdvanced pancreatic neuroendocrine tumorsTwo-stage phase II trialObjective tumor responsePhase II studyPhase II trialContinuous dosing scheduleStage 1Lack of responseEligible patientsMedian OSMedian PFSII trialAdverse eventsII studyObjective responseDosing schedulesTumor responseClinical activityPatientsMTOR pathwayMTORC1/2 inhibitors
2014
Outcomes and toxicity of SBRT for patients with unresectable pancreatic adenocarcinoma.
Pollom E, Alagappan M, Chan C, Shultz D, Kunz P, Koong A, Chang D. Outcomes and toxicity of SBRT for patients with unresectable pancreatic adenocarcinoma. Journal Of Clinical Oncology 2014, 32: 317-317. DOI: 10.1200/jco.2014.32.3_suppl.317.Peer-Reviewed Original ResearchStereotactic body radiotherapyUnresectable pancreatic adenocarcinomaGy x 5Pancreatic adenocarcinomaPrior RTCurrent chemoResectable diseaseTumor locationTime of SBRTToxicity of SBRTLocal controlBorderline resectable diseaseGood local controlUse of chemotherapyDate of diagnosisCommon treatment regimensBetter OSMedian OSOS ratesAdvanced diseaseGI toxicityCumulative incidenceLocal recurrenceBody radiotherapyTreatment regimens
2011
Long-term survivorship in gastric cancer.
Kunz P, Gubens M, Fisher G, Ford J, Lichtensztajn D, Clarke C. Long-term survivorship in gastric cancer. Journal Of Clinical Oncology 2011, 29: 14-14. DOI: 10.1200/jco.2011.29.4_suppl.14.Peer-Reviewed Original ResearchGastric cancerIntestinal histologyGEJ cancerAnatomic sitesAsian/Pacific Islander raceEsophagus/cardiaLonger median OSOutcomes of survivalCalifornia Cancer RegistryYear of diagnosisGastroesophageal junction adenocarcinomaPacific Islander raceCause-specific deathKaplan-Meier curvesLong-term survivorsStrong independent predictorCases of gastricAsian/Pacific IslandersLong-term survivorshipNon-Hispanic whitesHigher SESLogistic regression modelsMedian OSMedian ageIndependent predictors