Age- and sex-based differences in the genomic profiles of patients with gastrointestinal (GI) and pancreatic neuroendocrine neoplasms (NENs).
Liu L, Li S, Gandhi N, Farrell A, Lou E, Soares H, Nazha B, Swensen J, Oberley M, Nabhan C, Abraham J, Korn W, Kunz P, Vijayvergia N. Age- and sex-based differences in the genomic profiles of patients with gastrointestinal (GI) and pancreatic neuroendocrine neoplasms (NENs). Journal Of Clinical Oncology 2023, 41: 655-655. DOI: 10.1200/jco.2023.41.4_suppl.655.Peer-Reviewed Original ResearchNeuroendocrine neoplasmsPancreatic neuroendocrine neoplasmsP-NENsGI-NENGI-NENsImmune profileKRAS mutationsImmune checkpoint gene expressionHigh tumor mutation burdenCaris Life SciencesDMMR/MSIDistinct immune profilesTumor mutation burdenYears of ageMechanisms of ageWhole-exome sequencingMann-Whitney USex-based differencesSite of originDistinct molecular profilesICGs expressionAge-associated effectsOverall survivalPatient demographicsImmune landscape