2024
Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios
Wilson M, Romano S, Khatri N, Aharon D, Liu Y, Kaufman O, Draper B, Marlow F. Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios. Nature Communications 2024, 15: 5248. PMID: 38898112, PMCID: PMC11187175, DOI: 10.1038/s41467-024-49613-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleGene Expression Regulation, DevelopmentalMaleMechanistic Target of Rapamycin Complex 1Nuclear Pore Complex ProteinsNutrientsOocytesOogenesisOvaryRNA-Binding ProteinsSignal TransductionTestisZebrafishZebrafish ProteinsConceptsRibosome biogenesis factorsRNA-binding proteinsMTORC1 signaling pathwayBipotential stateBiogenesis factorsGAP activityFemale fateTranslational regulationReproductive successGenetic analysisFate switchZebrafish oogenesisBinding proteinSignaling pathwayRBPMS2Oocyte progressionRAG-2Oocyte factorsZebrafishPrimary gonadsDifferentiation factorPathwayFateRNAbpsRibosome
2018
rbpms2 functions in Balbiani body architecture and ovary fate
Kaufman O, Lee K, Martin M, Rothhämel S, Marlow F. rbpms2 functions in Balbiani body architecture and ovary fate. PLOS Genetics 2018, 14: e1007489. PMID: 29975683, PMCID: PMC6049948, DOI: 10.1371/journal.pgen.1007489.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell PolarityCytoplasmEmbryo, NonmammalianFemaleGene Expression Regulation, DevelopmentalGerm CellsMaleMitochondriaMutagenesis, Site-DirectedOocytesOogenesisOvaryRNA-Binding ProteinsSex DifferentiationTumor Suppressor Protein p53ZebrafishZebrafish ProteinsConceptsRNA-binding proteinsPrimordial germ cellsGerm cellsIntact RNA binding domainLocalized to subcellular compartmentsRNA-binding domainGerm granulesProtein domainsElectron-dense cytoplasmic inclusionsMutations of TP53Accumulation of mitochondriaPromote oogenesisRibonucleoprotein granulesSubcellular compartmentsBinding domainAsymmetric accumulationDevelopmental regulationFertile malesBalbiani bodyOocyte differentiationMutantsBlastula cellsSexual differentiationSomatic cellsBody architecture