2022
The first 20 months of the COVID-19 pandemic: Mortality, intubation and ICU rates among 104,590 patients hospitalized at 21 United States health systems
Fiore M, Smith S, Adsit R, Bolt D, Conner K, Bernstein S, Eng O, Lazuk D, Gonzalez A, Jorenby D, D’Angelo H, Kirsch J, Williams B, Nolan M, Hayes-Birchler T, Kent S, Kim H, Piasecki T, Slutske W, Lubanski S, Yu M, Suk Y, Cai Y, Kashyap N, Mathew J, McMahan G, Rolland B, Tindle H, Warren G, An L, Boyd A, Brunzell D, Carrillo V, Chen L, Davis J, Dilip D, Ellerbeck E, Iturrate E, Jose T, Khanna N, King A, Klass E, Newman M, Shoenbill K, Tong E, Tsoh J, Wilson K, Theobald W, Baker T. The first 20 months of the COVID-19 pandemic: Mortality, intubation and ICU rates among 104,590 patients hospitalized at 21 United States health systems. PLOS ONE 2022, 17: e0274571. PMID: 36170336, PMCID: PMC9518859, DOI: 10.1371/journal.pone.0274571.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsICU admission rateUnited States health systemState health systemAdmission ratesPositive COVID-19 PCR testCOVID-19 PCR testHospitalized COVID-19 patientsHealth systemHealth system contactElectronic health record dataICD-10 diagnosisAge 18 yearsCOVID-19 hospitalizationRisk-standardized mortalityHealth record dataHigh mortality rateCOVID-19 pandemicICU admissionHospitalized participantsEndotracheal intubationIntubation rateMean agePatient groupPatient outcomesRelations of Current and Past Cancer with Severe Outcomes among 104,590 Hospitalized COVID-19 Patients: The COVID EHR Cohort at the University of Wisconsin
Nolan M, Piasecki T, Smith S, Baker T, Fiore M, Adsit R, Bolt D, Conner K, Bernstein S, Eng O, Lazuk D, Gonzalez A, Hayes-Birchler T, Jorenby D, D'Angelo H, Kirsch J, Williams B, Kent S, Kim H, Lubanski S, Yu M, Suk Y, Cai Y, Kashyap N, Mathew J, McMahan G, Rolland B, Tindle H, Warren G, Abu-el-rub N, An L, Boyd A, Brunzell D, Carrillo V, Chen L, Davis J, Deshmukh V, Dilip D, Goldstein A, Ha P, Iturrate E, Jose T, Khanna N, King A, Klass E, Lui M, Mermelstein R, Poon C, Tong E, Wilson K, Theobald W, Slutske W. Relations of Current and Past Cancer with Severe Outcomes among 104,590 Hospitalized COVID-19 Patients: The COVID EHR Cohort at the University of Wisconsin. Cancer Epidemiology Biomarkers & Prevention 2022, 32: 12-21. PMID: 35965473, PMCID: PMC9827105, DOI: 10.1158/1055-9965.epi-22-0500.Peer-Reviewed Original ResearchConceptsSevere COVID-19 outcomesCOVID-19 outcomesCurrent cancerCOVID-19 vaccinationPast cancerICU admissionSevere outcomesCancer typesCancer diagnosisHistory of cancerElectronic health record dataCOVID-19 patientsHealth record dataUnited States health systemCOVID-19State health systemEHR cohortHospital mortalityVaccination statusYounger patientsPatient characteristicsCancer characteristicsMost cancer typesOdds ratioHigh risk
2021
Racial disparities in the SOFA score among patients hospitalized with COVID-19
Tolchin B, Oladele C, Galusha D, Kashyap N, Showstark M, Bonito J, Salazar MC, Herbst JL, Martino S, Kim N, Nash KA, Tiako M, Roy S, Greeno R, Jubanyik K. Racial disparities in the SOFA score among patients hospitalized with COVID-19. PLOS ONE 2021, 16: e0257608. PMID: 34535009, PMCID: PMC8448580, DOI: 10.1371/journal.pone.0257608.Peer-Reviewed Original ResearchConceptsNon-Hispanic white patientsNon-Hispanic black patientsNon-Hispanic blacksSOFA scoreHours of admissionNon-Hispanic whitesWhite patientsHispanic patientsBlack patientsCOVID-19Yale New Haven Health SystemSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreElevated SOFA scoreRetrospective cohort studyCrisis standardsMedical resourcesFull multivariate modelHospital mortalityCohort studyConsecutive patientsMedian agePrimary outcomeFirst admissionInclusion criteriaThe potential impact of triage protocols on racial disparities in clinical outcomes among COVID-positive patients in a large academic healthcare system
Roy S, Showstark M, Tolchin B, Kashyap N, Bonito J, Salazar MC, Herbst JL, Nash KA, Tiako M, Jubanyik K, Kim N, Galusha D, Wang KH, Oladele C. The potential impact of triage protocols on racial disparities in clinical outcomes among COVID-positive patients in a large academic healthcare system. PLOS ONE 2021, 16: e0256763. PMID: 34529684, PMCID: PMC8445412, DOI: 10.1371/journal.pone.0256763.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlack or African AmericanConnecticutCOVID-19Delivery of Health CareFemaleHealthcare DisparitiesHispanic or LatinoHospital MortalityHospitals, UniversityHumansMaleMiddle AgedOrgan Dysfunction ScoresPandemicsRetrospective StudiesSARS-CoV-2TriageWhite PeopleYoung AdultConceptsCOVID-positive patientsHigher SOFA scoreSOFA scoreClinical outcomesBlack patientsHospital mortalityICU admissionTriage protocolYale New Haven Health SystemSequential Organ Failure Assessment scoreHealthcare systemLarge academic healthcare systemOrgan Failure Assessment scoreRacial disparitiesSimilar clinical outcomesWorse clinical outcomesAcademic healthcare systemChi-square testRace/ethnicityPredictors of interestRetrospective cohortWhite patientsInsurance statusCOVID patientsTriage toolREVeAL-HF Design and Rationale of a Pragmatic Randomized Controlled Trial Embedded Within Routine Clinical Practice
Ahmad T, Yamamoto Y, Biswas A, Ghazi L, Martin M, Simonov M, Hsiao A, Kashyap N, Velazquez EJ, Desai NR, Wilson FP. REVeAL-HF Design and Rationale of a Pragmatic Randomized Controlled Trial Embedded Within Routine Clinical Practice. JACC Heart Failure 2021, 9: 409-419. PMID: 33992566, DOI: 10.1016/j.jchf.2021.03.006.Peer-Reviewed Original ResearchConceptsHeart failurePatient outcomesClinical decision makingN-terminal pro-B-type natriuretic peptide levelsPro-B-type natriuretic peptide levelsPragmatic Randomized Controlled TrialIntravenous diuretic agentsNatriuretic peptide levelsRandomized Controlled TrialsRoutine clinical practiceEvidence-based interventionsElectronic health recordsControlled TrialsPatient populationAccurate prognosticationCommon causeDiuretic agentsPeptide levelsClinical practicePg/TrialsHealth recordsSignificant riskMortalityOutcomes