2017
Circulating Epithelial Cells in Intraductal Papillary Mucinous Neoplasms and Cystic Pancreatic Lesions
Poruk KE, Valero V, He J, Ahuja N, Cameron JL, Weiss MJ, Lennon AM, Goggins M, Wood LD, Wolfgang CL. Circulating Epithelial Cells in Intraductal Papillary Mucinous Neoplasms and Cystic Pancreatic Lesions. Pancreas 2017, 46: 943-947. PMID: 28697136, DOI: 10.1097/mpa.0000000000000869.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmHigh-grade dysplasiaPapillary mucinous neoplasmBlood of patientsEpithelial cellsMucinous neoplasmsPancreatic lesionsAbsence of malignancyBenign pancreatic lesionsCystic pancreatic lesionsNineteen patientsPancreatic resectionPeripheral bloodPancreatic cystsISET methodPatientsPancreas-specific markersResectionMalignancyDysplasiaBloodNeoplasmsPancreatic sourceLow gradeLesions
2016
A Contemporary Evaluation of the Cause of Death and Long‐Term Quality of Life After Total Pancreatectomy
Wu W, Dodson R, Makary MA, Weiss MJ, Hirose K, Cameron JL, Ahuja N, Pawlik TM, Wolfgang CL, He J. A Contemporary Evaluation of the Cause of Death and Long‐Term Quality of Life After Total Pancreatectomy. World Journal Of Surgery 2016, 40: 2513-2518. PMID: 27177647, DOI: 10.1007/s00268-016-3552-8.Peer-Reviewed Original ResearchConceptsCause of deathTotal pancreatectomyInsulin-dependent diabetesDiabetes-dependent QoLSF-36 surveyShort Form-36Majority of deathsLong-term qualityTotal hospitalizationsForm-36Preoperative stateDiabetes complicationsPreoperative assessmentWorse QoLDiabetic complicationsQOL surveyDiffuse diseasePatientsPancreatic enzymesQoLEuropean OrganizationHealth changesLife implicationsDeathPancreatectomy
2015
Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma
Rezaee N, Barbon C, Zaki A, He J, Salman B, Hruban RH, Cameron JL, Herman JM, Ahuja N, Lennon AM, Weiss MJ, Wood LD, Wolfgang CL. Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma. Hepato Pancreato Biliary 2015, 18: 236-246. PMID: 27017163, PMCID: PMC4814593, DOI: 10.1016/j.hpb.2015.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Pancreatic DuctalDatabases, FactualDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeoplasms, Cystic, Mucinous, and SerousNeoplasms, Second PrimaryPancreatectomyPancreatic NeoplasmsProportional Hazards ModelsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsIntraductal papillary mucinous neoplasmHigh-grade dysplasiaPancreatic ductal adenocarcinomaNon-invasive intraductal papillary mucinous neoplasmsIntermediate-grade dysplasiaPapillary mucinous neoplasmRemnant pancreasVascular invasionMucinous neoplasmsDuctal adenocarcinomaInvasive pancreatic ductal adenocarcinomaMedian overall survivalLymph node metastasisRate of progressionSubsequent developmentIntermediate dysplasiaPancreatic resectionOverall survivalNode metastasisPerineural invasionMalignant entitiesRisk factorsPatientsDysplasiaPancreasEarly hospital readmission for gastrointestinal-related complications predicts long-term mortality after pancreatectomy
Hicks CW, Tosoian JJ, Craig-Schapiro R, Valero V, Cameron JL, Eckhauser FE, Hirose K, Makary MA, Pawlik TM, Ahuja N, Weiss MJ, Wolfgang CL. Early hospital readmission for gastrointestinal-related complications predicts long-term mortality after pancreatectomy. The American Journal Of Surgery 2015, 210: 636-642.e1. PMID: 26384793, PMCID: PMC4634566, DOI: 10.1016/j.amjsurg.2015.05.009.Peer-Reviewed Original ResearchConceptsEarly hospital readmissionHospital readmissionOverall mortalityLong-term mortalitySignificant independent predictorsBaseline group differencesPancreatectomy patientsIndependent predictorsPrognostic significanceInstitutional databaseRisk factorsPancreatectomyMultivariate analysisReadmissionMortalityComplicationsPatientsAdditional studiesGroup differencesStatewide datasetMorbiditySocial factorsTracking Early Readmission After Pancreatectomy to Index and Nonindex Institutions: A More Accurate Assessment of Readmission
Tosoian JJ, Hicks CW, Cameron JL, Valero V, Eckhauser FE, Hirose K, Makary MA, Pawlik TM, Ahuja N, Weiss MJ, Wolfgang CL. Tracking Early Readmission After Pancreatectomy to Index and Nonindex Institutions: A More Accurate Assessment of Readmission. JAMA Surgery 2015, 150: 152-158. PMID: 25535811, PMCID: PMC4461067, DOI: 10.1001/jamasurg.2014.2346.Peer-Reviewed Original ResearchConceptsTertiary care referral centerPatient-level factorsNonindex hospitalEarly readmissionReferral centerMultivariable analysisPatterns of readmissionPostoperative drain placementRate of readmissionRisk of readmissionData of patientsAge 65 yearsHigh-volume institutionsDistal pancreatectomyPostoperative infectionPrimary outcomeLiver diseaseDrain placementInstitutional databaseRisk factorsPancreatectomyRetrospective analysisReadmissionMAIN OUTCOMEPatients
2014
A Systematic Review of Solid-Pseudopapillary Neoplasms
Law JK, Ahmed A, Singh VK, Akshintala VS, Olson MT, Raman SP, Ali SZ, Fishman EK, Kamel I, Canto MI, Dal Molin M, Moran RA, Khashab MA, Ahuja N, Goggins M, Hruban RH, Wolfgang CL, Lennon AM. A Systematic Review of Solid-Pseudopapillary Neoplasms. Pancreas 2014, 43: 331-337. PMID: 24622060, PMCID: PMC4888067, DOI: 10.1097/mpa.0000000000000061.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCarcinoma, PapillaryDisease-Free SurvivalFemaleHumansMalePancreatectomyPancreatic NeoplasmsYoung AdultConceptsSolid pseudopapillary neoplasmSystematic reviewExcellent long-term prognosisDisease-free survivalMainstay of treatmentMean tumor sizeLong-term prognosisAbdominal painNonspecific symptomsPancreatic resectionMedian timeCommon symptomsNeoplasm casesTumor sizeMean agePatientsNumber of casesYoung womenRecurrenceNeoplasmsSymptomsMonthsTotalPainResection
2013
Trends and Risk Factors for Transfusion in Hepatopancreatobiliary Surgery
Lucas DJ, Schexneider KI, Weiss M, Wolfgang CL, Frank SM, Hirose K, Ahuja N, Makary M, Cameron JL, Pawlik TM. Trends and Risk Factors for Transfusion in Hepatopancreatobiliary Surgery. Journal Of Gastrointestinal Surgery 2013, 18: 719-728. PMID: 24323432, DOI: 10.1007/s11605-013-2417-9.Peer-Reviewed Original ResearchConceptsRisk of transfusionRisk factorsPerioperative transfusionPreoperative hematocritBlood transfusionHPB proceduresPublic Use FilePatient-level risk factorsAnesthesiologists class IVIncidence of transfusionPerioperative blood transfusionPatient-level factorsHigh-risk factorsPatient-specific factorsHepatopancreatobiliary proceduresTransfusion utilizationPreoperative albuminTransfusion rateASA classificationPancreatic resectionHPB surgeryHepatopancreatobiliary surgeryProcedure typeInclusion criteriaTransfusionIs It Necessary to Follow Patients after Resection of a Benign Pancreatic Intraductal Papillary Mucinous Neoplasm?
He J, Cameron JL, Ahuja N, Makary MA, Hirose K, Choti MA, Schulick RD, Hruban RH, Pawlik TM, Wolfgang CL. Is It Necessary to Follow Patients after Resection of a Benign Pancreatic Intraductal Papillary Mucinous Neoplasm? Journal Of The American College Of Surgeons 2013, 216: 657-665. PMID: 23395158, PMCID: PMC3963007, DOI: 10.1016/j.jamcollsurg.2012.12.026.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmNoninvasive intraductal papillary mucinous neoplasmsPapillary mucinous neoplasmPancreatic cancerFamily historyMucinous neoplasmsNegative marginsInitial operationPancreatic intraductal papillary mucinous neoplasmsPartial pancreatic resectionMetastatic pancreatic adenocarcinomaInvasive pancreatic cancerRisk of developmentDegree of dysplasiaInitial surgeryMargin statusPancreatic resectionClose surveillanceInvasive adenocarcinomaPancreatic adenocarcinomaResectionPatientsCancerSurgeryAdenocarcinoma
2010
Is the Debate Finally Over?: Comment on “Survival Effects of Adjuvant Chemoradiation Following Chemoradiotherapy After Resection for Pancreatic Carcinoma”
Ahuja N. Is the Debate Finally Over?: Comment on “Survival Effects of Adjuvant Chemoradiation Following Chemoradiotherapy After Resection for Pancreatic Carcinoma”. JAMA Surgery 2010, 145: 56-56. PMID: 20088100, DOI: 10.1001/archsurg.2009.241.Peer-Reviewed Original Research
2009
Variations in Referral Patterns to High-Volume Centers for Pancreatic Cancer
Chang DC, Zhang Y, Mukherjee D, Wolfgang CL, Schulick RD, Cameron JL, Ahuja N. Variations in Referral Patterns to High-Volume Centers for Pancreatic Cancer. Journal Of The American College Of Surgeons 2009, 209: 720-726. PMID: 19959040, PMCID: PMC4036485, DOI: 10.1016/j.jamcollsurg.2009.09.011.Peer-Reviewed Original ResearchConceptsHigh-volume centersHigh-volume hospitalsNationwide Inpatient SamplePancreatic cancer patientsArea Resource FilePancreatic resectionCancer patientsInpatient SamplePancreatic cancerRadiation oncologistsCharlson Comorbidity Index scoreComorbidity Index scoreOdds of referralPrimary outcome variableResource FileCommunity poverty levelCalendar yearPatient ageOverall referralsReferral patternsVolume centersInsurance statusPrimary diagnosisInclusion criteriaRetrospective analysisSurgical Management of Solid-Pseudopapillary Neoplasms of the Pancreas (Franz or Hamoudi Tumors): A Large Single-Institutional Series
Reddy S, Cameron JL, Scudiere J, Hruban RH, Fishman EK, Ahuja N, Pawlik TM, Edil BH, Schulick RD, Wolfgang CL. Surgical Management of Solid-Pseudopapillary Neoplasms of the Pancreas (Franz or Hamoudi Tumors): A Large Single-Institutional Series. Journal Of The American College Of Surgeons 2009, 208: 950-957. PMID: 19476869, PMCID: PMC3109868, DOI: 10.1016/j.jamcollsurg.2009.01.044.Peer-Reviewed Original ResearchConceptsSolid pseudopapillary neoplasmMalignant potentialFormal surgical resectionMedian tumor sizeOutcomes of patientsLymph node metastasisRare pancreatic tumorR1 resectionAbdominal painR0 resectionR2 resectionInstitutional seriesMost patientsSurgical resectionUnrelated causesClinicopathologic characteristicsComplete resectionMedian ageNode metastasisDistant metastasisPerineural invasionSurgical managementCommon symptomsLongterm outcomesTumor size
2008
Pancreatic Resection of Isolated Metastases from Nonpancreatic Primary Cancers
Reddy S, Edil BH, Cameron JL, Pawlik TM, Herman JM, Gilson MM, Campbell KA, Schulick RD, Ahuja N, Wolfgang CL. Pancreatic Resection of Isolated Metastases from Nonpancreatic Primary Cancers. Annals Of Surgical Oncology 2008, 15: 3199-3206. PMID: 18784960, DOI: 10.1245/s10434-008-0140-7.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaPancreatic resectionMetachronous lesionsMetastatic lesionsVascular invasionConclusionLong-term survivalResultsForty-nine patientsLymph node metastasisLangerhans cell histiocytosisDistal pancreatectomyPerioperative deathsPostoperative morbidityTotal pancreatectomyIsolated metastasisMedian survivalMetastatic diseaseSynchronous lesionsNode metastasisPrimary diseasePrimary cancerMedian lengthCell carcinomaGallbladder cancerSingle institutionCell histiocytosisWhat Constitutes a “High-Volume” Hospital for Pancreatic Resection?
Meguid RA, Ahuja N, Chang DC. What Constitutes a “High-Volume” Hospital for Pancreatic Resection? Journal Of The American College Of Surgeons 2008, 206: 622.e1-622.e9. PMID: 18387466, DOI: 10.1016/j.jamcollsurg.2007.11.011.Peer-Reviewed Original ResearchConceptsPancreatic resectionResection volumeCenters of excellenceNationwide Inpatient SampleMultivariable logistic regressionImproved postoperative outcomesHospital mortalityPostoperative mortalityPerioperative deathsPostoperative outcomesInpatient SampleRetrospective analysisResectionVolume thresholdImperfect surrogateLogistic regressionPatients