Combining Epigenetic and Immunotherapy to Combat Cancer
Chiappinelli KB, Zahnow CA, Ahuja N, Baylin SB. Combining Epigenetic and Immunotherapy to Combat Cancer. Cancer Research 2016, 76: 1683-1689. PMID: 26988985, PMCID: PMC4873370, DOI: 10.1158/0008-5472.can-15-2125.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitor efficacyCheckpoint inhibitor efficacyImmune checkpoint blockadeCurrent clinical trialsT-cell attractionException of melanomaAdvanced human cancersCancer management strategiesEpithelial cancer cellsCheckpoint blockadeMost patientsCombination therapyCancer testisClinical trialsDNA methyltransferase inhibitorMouse modelInhibitor efficacyImmune signalingCancer cellsHuman cancersMethyltransferase inhibitorEpigenetic drugsDemethylating agentExciting recent advancesEndogenous retroviruses