2007
Subclassification of microsatellite-unstable tumors in colorectal cancer
Ahuja N, Baylin S. Subclassification of microsatellite-unstable tumors in colorectal cancer. Current Colorectal Cancer Reports 2007, 3: 212-219. DOI: 10.1007/s11888-007-0033-3.Peer-Reviewed Original ResearchHereditary nonpolyposis colorectal cancerSporadic colorectal cancerColorectal cancerMMR genes MLH1Nonpolyposis colorectal cancerK-ras mutationsBRAF V600E mutationMicrosatellite-unstable tumorsMismatch repair genesVillous adenomaPathologic differencesHNPCC tumorsInherited syndromeTumor typesPolyp pathwayMicrosatellite instabilityCancerGermline mutationsMMR genesGenes MLH1TumorsInherited mutationsRepair genesMutationsEpigenetic silencing
1998
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
Herman J, Umar A, Polyak K, Graff J, Ahuja N, Issa J, Markowitz S, Willson J, Hamilton S, Kinzler K, Kane M, Kolodner R, Vogelstein B, Kunkel T, Baylin S. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6870-6875. PMID: 9618505, PMCID: PMC22665, DOI: 10.1073/pnas.95.12.6870.Peer-Reviewed Original ResearchConceptsCpG islandsMismatch repair genesCell linesDNA mismatch repairMMR-deficient cell linesDNA methylationSuch methylationSporadic primary colorectal cancerEpigenetic inactivationMMR capacityMismatch repairRepair genesMethylationFunctional consequencesColorectal cancer cell linesCancer cell linesPromoter hypermethylationHypermethylationMicrosatellite instabilityProtein expressionHMLH1 proteinGenesColorectal cancerHMLH1 protein expressionInactivation