2019
Targeting the epigenome of pancreatic cancer for therapy: challenges and opportunities
Baretti M, Ahuja N, Azad N. Targeting the epigenome of pancreatic cancer for therapy: challenges and opportunities. Annals Of Pancreatic Cancer 2019, 2: 18-18. DOI: 10.21037/apc.2019.10.01.Peer-Reviewed Original ResearchEpigenetic modulatory drugsEpigenetic alterationsGene expressionImmediate translational implicationsProgression of PAADEpigenetic regulationHeritable differencesEpigenetic abnormalitiesPrimary sequenceTumor microenvironmentNucleosomesEssential roleCurrent knowledgeTranslational applicationsComplex seriesDNATranslational implicationsNew therapeutic approachesExpressionPancreatic adenocarcinomaEpigenomeChromatinEpigeneticsSubsequent interactionAlterations
2000
Aging, methylation and cancer.
Ahuja N, Issa JP. Aging, methylation and cancer. Cellular And Molecular Biology 2000, 15: 835-42. PMID: 10963127, DOI: 10.14670/hh-15.835.Peer-Reviewed Original ResearchConceptsAge-related methylationSuch age-related methylationPromoter-associated CpG islandsTumor suppressor geneGene functionDNA methylationCpG islandsMethylation changesFull methylationGene expressionMethylationGenesNovel targetNormal cellsColon cancerAlternate mechanismMost cancersEvidence pointsFundamental markMyoDIGF2HypermethylationDNAERMutations