2016
Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice
Tai N, Peng J, Liu F, Gulden E, Hu Y, Zhang X, Chen L, Wong FS, Wen L. Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice. Journal Of Experimental Medicine 2016, 213: 2129-2146. PMID: 27621416, PMCID: PMC5030808, DOI: 10.1084/jem.20160526.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, BacterialCD8-Positive T-LymphocytesCell DifferentiationDiabetes Mellitus, ExperimentalFemaleGastrointestinal MicrobiomeGlucose-6-PhosphataseLymphocyte ActivationMice, Inbred C57BLMice, Inbred NODMyeloid Differentiation Factor 88PeptidesReceptors, Antigen, T-CellThymus GlandT-Lymphocytes, RegulatoryConceptsCD8 T cellsT cellsCommensal bacteriaSignificant homologyDiabetes developmentGut microbiotaDiabetogenic CD8 T cellsPathogenic CD8 T cellsTransgenic nonobese diabetic miceGut microbesType 1 diabetes developmentIslet-specific glucose-6-phosphatase catalytic subunit-related proteinNovel mechanismNonobese diabetic (NOD) miceInnate immunityBacteriaMolecular mimicryNOD miceIslet autoantigensT1D developmentDiabetic miceMicrobial antigensCellsAnimal modelsHuman studiesThe induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model
Yuksel M, Xiao X, Tai N, Vijay M, Gülden E, Beland K, Lapierre P, Alvarez F, Hu Z, Colle I, Ma Y, Wen L. The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model. Clinical & Experimental Immunology 2016, 186: 164-176. PMID: 27414259, PMCID: PMC5054566, DOI: 10.1111/cei.12843.Peer-Reviewed Original ResearchMeSH KeywordsAmmonia-LyasesAnimalsAntigen-Presenting CellsAutoantibodiesAutoantigensCD8-Positive T-LymphocytesCytochrome P-450 CYP2D6CytokinesDisease Models, AnimalGlutamate FormimidoyltransferaseHepatitis, AutoimmuneHLA-DR4 AntigenHumansHypergammaglobulinemiaImmunizationImmunoglobulin GInflammation MediatorsMiceMice, Inbred NODMice, TransgenicMultienzyme ComplexesMultifunctional EnzymesPlasma CellsT-Lymphocyte SubsetsConceptsDevelopment of AIHAutoimmune hepatitisHLA-DR4DR4 miceT cellsAnti-liver kidney microsomal type 1Anti-liver cytosol type 1Induction of AIHWild-type NOD miceNon-obese diabetic (NOD) miceType 1Key immune cell subsetsAnti-smooth muscle actinAdult autoimmune hepatitisHepatitis mouse modelElevated alanine aminotransferasePD-1 expressionPlasma cell infiltrationChronic liver diseaseRegulatory T cellsMild liver injuryImmune cell subsetsPersistent liver damageAntigen-presenting cellsHuman leucocyte antigen
2009
Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice
Xiao X, Ma B, Dong B, Zhao P, Tai N, Chen L, Wong FS, Wen L. Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. Journal Of Autoimmunity 2009, 32: 85-93. PMID: 19200691, DOI: 10.1016/j.jaut.2008.12.003.Peer-Reviewed Original ResearchConceptsDiabetic NOD miceNOD miceDiabetic nephropathyDiabetic miceNon-diabetic NOD miceNon-obese diabetic (NOD) miceDuration of diabetesUrinary albumin excretionAdditional therapeutic targetsHumoral immune responseAlbumin excretionAutoimmune diabetesDendritic cellsDiabetes onsetImmune changesKidney weightIgG depositsHumoral immunityT cellsImmune responseNephropathyComplement C3Therapeutic targetB cellsImmune system