2022
Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis
Dillon GA, Stanhewicz AE, Serviente C, Flores VA, Stachenfeld N, Alexander LM. Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis. Microvascular Research 2022, 144: 104421. PMID: 35970408, PMCID: PMC9527706, DOI: 10.1016/j.mvr.2022.104421.Peer-Reviewed Original ResearchConceptsEndothelium-dependent vasodilationLaser Doppler fluxEndothelial functionCardiovascular diseaseOral atorvastatinExerts potent anti-inflammatory effectsEndothelium-dependent agonist acetylcholineShort-term statin administrationPotent anti-inflammatory effectsIntradermal microdialysis perfusionNO-dependent dilationImpaired endothelial functionMicrovascular endothelial functionCutaneous microvascular functionCutaneous vascular conductanceAnti-inflammatory effectsNO-dependent vasodilationNO synthase inhibitorDose-response curveStatin therapyAdjunctive therapyAtorvastatin treatmentCVD riskEndothelial dysfunctionStatin administration
2015
Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance
Wenner MM, Taylor HS, Stachenfeld NS. Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance. Microcirculation 2015, 22: 391-399. PMID: 25996650, PMCID: PMC4506724, DOI: 10.1111/micc.12208.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultEstradiolFemaleGenisteinHumansInsulin ResistanceMicrocirculationMicrovesselsVasodilationConceptsL-NMMAMicrovascular vasodilationHealthy womenVasodilatory responsivenessLocal cutaneous heatingMicrovascular vasodilatory functionMicrovascular vasodilatory responsesBeat blood pressureHealthy young womenLaser Doppler flowmetryHeat-induced vasodilationMicrovascular responsivenessVascular effectsVasodilatory responseBlood pressureMicrovascular functionVasodilatory functionCutaneous heatingInsulin resistanceCutaneous circulationDoppler flowmetryGEN exposureInteraction of E2VasodilationMicrodialysis perfusion
1997
Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia
Haskell A, Nadel E, Stachenfeld N, Nagashima K, Mack G. Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia. Journal Of Applied Physiology 1997, 83: 407-413. PMID: 9262434, DOI: 10.1152/jappl.1997.83.2.407.Peer-Reviewed Original ResearchConceptsCapillary filtration coefficientTranscapillary escape rateLeg musclesUpright cycle ergometer exerciseVascular spaceTranscapillary forcesInterstitial fluid hydrostatic pressureCycle ergometer exercisePlasma albumin concentrationPlasma colloid osmotic pressureExercise-induced hypervolemiaColloid osmotic pressureErgometer exerciseIntense exerciseTotal protein concentrationFluid hydrostatic pressureAlbumin concentrationTERalbMuscleFiltration coefficientExerciseActive tissuesAlbuminLegProtein concentration