2023
Effects of androgen excess and body mass index on endothelial function in women with polycystic ovary syndrome
Berbrier D, Leone C, Adler T, Bender J, Taylor H, Stachenfeld N, Usselman C. Effects of androgen excess and body mass index on endothelial function in women with polycystic ovary syndrome. Journal Of Applied Physiology 2023, 134: 868-878. PMID: 36861670, DOI: 10.1152/japplphysiol.00583.2022.Peer-Reviewed Original ResearchMeSH KeywordsAndrogensBody Mass IndexEthinyl EstradiolFemaleHumansObesityOverweightPolycystic Ovary SyndromeTestosteroneConceptsPolycystic ovary syndromeEndothelial dysfunctionEndothelial functionOvary syndromeAndrogen excessLean womenObese womenEstradiol supplementationLow flow-mediated constrictionOW/OB groupOverweight/obese womenMarked endothelial dysfunctionSevere endothelial dysfunctionFree testosterone levelsBody mass indexFlow-mediated dilation (FMD) testFree testosteroneMass indexReactive hyperemiaOB groupTestosterone levelsHealth differEndothelial pathophysiologyDysfunctionAndrogens
2019
Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman CW, Yarovinsky T, Steele FE, Leone CA, Taylor HS, Bender JR, Stachenfeld NS. Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor. The Journal Of Physiology 2019, 597: 2853-2865. PMID: 30847930, DOI: 10.1113/jp277756.Peer-Reviewed Original ResearchMeSH KeywordsAdultAndrogensCardiovascular DiseasesDihydrotestosteroneEndothelin-1Endothelium, VascularEstrogensEthinyl EstradiolFemaleGlucose Tolerance TestHumansMicrovesselsNitric OxideObesityPolycystic Ovary SyndromeReceptor, Endothelin BSkinVascular Endothelial Growth Factor AVasodilationYoung AdultConceptsPolycystic ovary syndromeCardiovascular dysfunctionEndothelial dysfunctionOvary syndromeEndothelin-1Endothelial functionNO productionAndrogen receptor-dependent mannerEndothelin-B receptor subtypeCardiovascular risk factorsMicrovascular endothelial dysfunctionMicrovascular endothelial functionCutaneous vascular conductanceB receptor subtypesEndothelin B receptorLaser Doppler flowmetryNitric oxide inhibitionReceptor-dependent mannerEndothelial cell NO productionDose-response curveVasodilating responsePCOS subjectsLean womenObese womenVascular conductance
2018
Blood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women
Adler TE, Usselman CW, Takamata A, Stachenfeld NS. Blood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women. AJP Heart And Circulatory Physiology 2018, 315: h925-h933. PMID: 29906227, DOI: 10.1152/ajpheart.00188.2018.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdministration, OralAdolescentAdultAntihypertensive AgentsArterial PressureBrachial ArteryDrug Administration ScheduleEndothelium, VascularEthinyl EstradiolExercise TestFemaleHand StrengthHumansHypertensionIschemiaObesityTime FactorsTreatment OutcomeVasodilator AgentsYoung AdultConceptsEthinyl estradiol administrationEndothelial functionBlood pressureEstradiol administrationEthinyl estradiol exposureEndothelial dysfunctionShear stress stimulusEndothelial impairmentEstradiol exposureHBP groupExercise responseNBP groupFlow-mediated dilation responseHigh blood pressure groupYoung womenIschemic handgrip exerciseOral ethinyl estradiolOvert cardiovascular dysfunctionBlood pressure groupFlow-mediated dilationNormal blood pressureHigh blood pressureMild hypertensionFMD responseHandgrip exercise