2014
Hormonal Changes During Menopause and the Impact on Fluid Regulation
Stachenfeld NS. Hormonal Changes During Menopause and the Impact on Fluid Regulation. Reproductive Sciences 2014, 21: 555-561. PMID: 24492487, PMCID: PMC3984489, DOI: 10.1177/1933719113518992.Peer-Reviewed Original ResearchConceptsHormone therapySodium retentionMenopausal womenFluid regulationCardiovascular functionAldosterone-mediated sodium retentionRisk of hyponatremiaBlood pressure responseFemale reproductive hormonesFluid-regulating hormonesBody fluid volumeRisk of dehydrationBody fluid regulationEstrogen therapyHypervolemic hyponatremiaCardiovascular riskEstradiol effectsSodium loadProgesterone exposureMineralocorticoid receptorProgestogen exposureReproductive hormonesReproductive surgeryHormonal changesDistal tubules
2009
Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia
Stachenfeld NS, Taylor HS. Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia. Journal Of Applied Physiology 2009, 107: 864-872. PMID: 19556454, DOI: 10.1152/japplphysiol.91211.2008.Peer-Reviewed Original ResearchConceptsExercise-associated hyponatremiaSodium lossGonadotropin-releasing hormone antagonistPeak oxygen consumptionMin of exerciseHistory of hyponatremiaHigh water intakeGnRH-antFluid retentionHormone antagonistProgesterone exposureEndurance exerciseDay 4Hormone effectsDay 13HyponatremiaSodium regulationHormone conditionsWomenHypoWater intakeOxygen consumptionProgesteroneExerciseLittle fall
2008
Sex Hormone Effects on Body Fluid Regulation
Stachenfeld NS. Sex Hormone Effects on Body Fluid Regulation. Exercise And Sport Sciences Reviews 2008, 36: 152-159. PMID: 18580296, PMCID: PMC2849969, DOI: 10.1097/jes.0b013e31817be928.Peer-Reviewed Original Research
2002
Estrogen effects on osmotic regulation of AVP and fluid balance
Stachenfeld NS, Keefe DL. Estrogen effects on osmotic regulation of AVP and fluid balance. AJP Endocrinology And Metabolism 2002, 283: e711-e721. PMID: 12217888, DOI: 10.1152/ajpendo.00192.2002.Peer-Reviewed Original ResearchConceptsHormone treatmentEstrogen effectsPlasma renin activityFree water clearanceEnd of recoveryIntrarenal effectsRenal sensitivityRenin activitySodium excretionFractional excretionAVP increaseSodium retentionFluid retentionLeuprolide acetateWater clearanceEndogenous estrogensAldosterone stimulationFluid balanceGnRHaNaCl infusionPg/EstrogenAVPProgesteroneExcretion
1999
Effects of oral contraceptives on body fluid regulation
Stachenfeld N, Silva C, Keefe D, Kokoszka C, Nadel E. Effects of oral contraceptives on body fluid regulation. Journal Of Applied Physiology 1999, 87: 1016-1025. PMID: 10484572, DOI: 10.1152/jappl.1999.87.3.1016.Peer-Reviewed Original ResearchConceptsBody fluid regulationLuteal phaseHighest plasma estradiol concentrationFluid regulationOral contraceptive administrationBody fluid retentionPlasma estradiol concentrationsMidluteal menstrual phasesBody fluid balanceArginine vasopressin concentrationBasal plasma osmolalityExercise dehydrationOral contraceptivesContraceptive administrationBody water balanceFluid retentionFollicular phaseEstradiol concentrationsAVP releaseMenstrual phaseFluid balanceVasopressin concentrationCrossover designThirst stimulationPlasma osmolalityPhysiological variability of fluid-regulation hormones in young women
Stachenfeld N, DiPietro L, Kokoszka C, Silva C, Keefe D, Nadel E. Physiological variability of fluid-regulation hormones in young women. Journal Of Applied Physiology 1999, 86: 1092-1096. PMID: 10066728, DOI: 10.1152/jappl.1999.86.3.1092.Peer-Reviewed Original ResearchConceptsPlasma renin activityEarly follicular phaseFollicular phaseMenstrual phaseMenstrual phase-related differencesAtrial natriuretic peptideDifferent menstrual phasesMean hormone concentrationsRenin activityNatriuretic peptideMidluteal phaseMenstrual cycleHormonal variablesPlasma concentrationsLuteal phaseHormone concentrationsPhase-related differencesYoung womenHormoneCronbach's alphaRehydration periodRestingAlphaMean concentrationPhysiological variability
1996
Thirst and fluid regulatory responses to hypertonicity in older adults
Stachenfeld N, Mack G, Takamata A, DiPietro L, Nadel E. Thirst and fluid regulatory responses to hypertonicity in older adults. American Journal Of Physiology 1996, 271: r757-r765. PMID: 8853401, DOI: 10.1152/ajpregu.1996.271.3.r757.Peer-Reviewed Original Research