2018
Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan
Stanhewicz AE, Wenner MM, Stachenfeld NS. Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan. AJP Heart And Circulatory Physiology 2018, 315: h1569-h1588. PMID: 30216121, PMCID: PMC6734083, DOI: 10.1152/ajpheart.00396.2018.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelial functionHealthy young womenCardiovascular diseaseVascular healthSex hormonesCardiovascular systemOverall cardiovascular disease riskSex differencesYoung womenAge-associated endothelial dysfunctionRenin-angiotensin systemPredictor of atherosclerosisAtherosclerotic cardiovascular diseaseCardiovascular disease riskCause of morbidityMale sex hormonesReceptor-independent mechanismVascular endothelinCVD riskEndothelial dysfunctionAge-related declineEarly decrementsFemale hormonesSimilar age-related declineCVD increasesBlood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women
Adler TE, Usselman CW, Takamata A, Stachenfeld NS. Blood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women. AJP Heart And Circulatory Physiology 2018, 315: h925-h933. PMID: 29906227, DOI: 10.1152/ajpheart.00188.2018.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdministration, OralAdolescentAdultAntihypertensive AgentsArterial PressureBrachial ArteryDrug Administration ScheduleEndothelium, VascularEthinyl EstradiolExercise TestFemaleHand StrengthHumansHypertensionIschemiaObesityTime FactorsTreatment OutcomeVasodilator AgentsYoung AdultConceptsEthinyl estradiol administrationEndothelial functionBlood pressureEstradiol administrationEthinyl estradiol exposureEndothelial dysfunctionShear stress stimulusEndothelial impairmentEstradiol exposureHBP groupExercise responseNBP groupFlow-mediated dilation responseHigh blood pressure groupYoung womenIschemic handgrip exerciseOral ethinyl estradiolOvert cardiovascular dysfunctionBlood pressure groupFlow-mediated dilationNormal blood pressureHigh blood pressureMild hypertensionFMD responseHandgrip exercise
2017
Water intake reverses dehydration associated impaired executive function in healthy young women
Stachenfeld NS, Leone CA, Mitchell E, Freese E, Harkness L. Water intake reverses dehydration associated impaired executive function in healthy young women. Physiology & Behavior 2017, 185: 103-111. PMID: 29277553, DOI: 10.1016/j.physbeh.2017.12.028.Peer-Reviewed Original ResearchConceptsExecutive functionDaily levelsCognitive tasksVisual-Analogue TestImpairs memoryMemory errorsCognitive functionHealthy young womenSensory perceptionSession 1MemoryBalanced orderSessionsControl sessionAnalog testDeficitsAdult womenEmotionsCognitionYoung womenDaily activitiesPerceptionTaskPhysical activityLearning
2014
Reproductive Hormone Influences on Thermoregulation in Women
Charkoudian N, Stachenfeld NS. Reproductive Hormone Influences on Thermoregulation in Women. 2014, 4: 793-804. PMID: 24715568, DOI: 10.1002/cphy.c130029.ChaptersConceptsReproductive hormonesHormone exposurePeripheral thermal informationReproductive hormone effectsMale reproductive hormonesBody temperatureThermoregulatory responsesProgesterone/progestinsPeripheral mechanismsAnterior hypothalamusPreoptic areaHormone influenceHormone effectsLow body temperatureBody heatingYoung womenThermoregulatory controlEnvironmental exposuresWomenHormoneMajor quantitative differencesProgestinsAndrogensEstrogenPhysiological thermoregulatory responses
2012
Blood pressure and water regulation: understanding sex hormone effects within and between men and women
Wenner MM, Stachenfeld NS. Blood pressure and water regulation: understanding sex hormone effects within and between men and women. The Journal Of Physiology 2012, 590: 5949-5961. PMID: 23027816, PMCID: PMC3530109, DOI: 10.1113/jphysiol.2012.236752.Peer-Reviewed Original ResearchConceptsOvarian hormone exposureBlood pressureHormone exposureHormone effectsYoung womenOvarian hormone effectsSuppress reproductive functionBlood pressure controlFirst-line treatmentSex differencesEffects of estrogenPlasma volume expansionCause of deathSex hormone effectsBody fluid regulationGreater morbidityHealthy womenLine treatmentOvarian hormonesMenopausal womenBody water balanceOrthostatic toleranceProgesterone exposureMenstrual cycleHormone administration
2008
Sex Hormone Effects on Body Fluid Regulation
Stachenfeld NS. Sex Hormone Effects on Body Fluid Regulation. Exercise And Sport Sciences Reviews 2008, 36: 152-159. PMID: 18580296, PMCID: PMC2849969, DOI: 10.1097/jes.0b013e31817be928.Peer-Reviewed Original Research
2007
Exogenous oestradiol and progesterone administration does not cause oedema in healthy young women
Stachenfeld NS, Taylor HS. Exogenous oestradiol and progesterone administration does not cause oedema in healthy young women. Clinical Endocrinology 2007, 66: 410-418. PMID: 17302877, DOI: 10.1111/j.1365-2265.2007.02748.x.Peer-Reviewed Original ResearchConceptsExtracellular fluid volumeTranscapillary albumin escape rateGonadotropin-releasing hormone antagonistPmol/Plasma renin activitySerum aldosterone concentrationHealthy young womenAlbumin escape rateRenin activityAldosterone concentrationGnRH antagonistHealthy womenProgesterone administrationExogenous oestradiolIntravascular volumeHormone antagonistProgesterone increaseDay 2Day 5Hormone treatmentOestradiolDay 13Extravascular componentOncotic pressureYoung women
2006
Effects of estradiol and medroxyprogesterone acetate on flow mediated dilation in young women
Meendering J, Torgrimson B, Kaplan P, Stachenfeld N, Minson C. Effects of estradiol and medroxyprogesterone acetate on flow mediated dilation in young women. The FASEB Journal 2006, 20: a301-a301. DOI: 10.1096/fasebj.20.4.a301-c.Peer-Reviewed Original ResearchMedroxyprogesterone acetateDay 5Day 10Gonadotropin-releasing hormone antagonistBaseline brachial artery diameterYoung womenEndothelial-dependent vasodilationBrachial artery diameterPreliminary dataMedical Research FoundationIndependent vasodilationDependent vasodilationBrachial arteryNitroglycerin administrationGnRHa administrationMPA administrationArtery diameterHormone antagonistEndogenous estrogensGnRHaVessel responsivenessDay 4Hormone treatmentAcute affectsE2
1999
Physiological variability of fluid-regulation hormones in young women
Stachenfeld N, DiPietro L, Kokoszka C, Silva C, Keefe D, Nadel E. Physiological variability of fluid-regulation hormones in young women. Journal Of Applied Physiology 1999, 86: 1092-1096. PMID: 10066728, DOI: 10.1152/jappl.1999.86.3.1092.Peer-Reviewed Original ResearchConceptsPlasma renin activityEarly follicular phaseFollicular phaseMenstrual phaseMenstrual phase-related differencesAtrial natriuretic peptideDifferent menstrual phasesMean hormone concentrationsRenin activityNatriuretic peptideMidluteal phaseMenstrual cycleHormonal variablesPlasma concentrationsLuteal phaseHormone concentrationsPhase-related differencesYoung womenHormoneCronbach's alphaRehydration periodRestingAlphaMean concentrationPhysiological variability