Testosterone lowers microvascular ET‐B receptor responsiveness in women with PCOS
Wenner M, Taylor H, Stachenfeld N. Testosterone lowers microvascular ET‐B receptor responsiveness in women with PCOS. The FASEB Journal 2011, 25: lb559-lb559. DOI: 10.1096/fasebj.25.1_supplement.lb559.Peer-Reviewed Original ResearchPolycystic ovary syndromeHeat-induced vasodilationT administrationCutaneous vascular conductance responsesET-1 plasma concentrationsET-B receptor antagonistImpaired microvascular functionET-B receptorsVascular conductance responsesEndogenous sex hormonesLaser Doppler flowmetryPCOS showOvary syndromeGnRH antagonistMicrovascular functionVascular dysfunctionReceptor antagonistReceptor responsivenessMicrodialysis infusionSex hormonesPlasma concentrationsDoppler flowmetryReceptor sensitivityT exposureTestosterone exposure