2023
Comment on “Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans”
Colburn A, Stachenfeld N. Comment on “Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans”. Journal Of Applied Physiology 2023, 135: 485-486. PMID: 37541850, DOI: 10.1152/japplphysiol.00335.2023.Peer-Reviewed Original ResearchLetter to the Editor in response to: Microvascular endothelial function following the cessation of long‐term oral contraceptive pill use: A case report
Kirby N, Stachenfeld N, Alexander L. Letter to the Editor in response to: Microvascular endothelial function following the cessation of long‐term oral contraceptive pill use: A case report. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2023, 108: 1092-1094. PMID: 37098953, PMCID: PMC10836611, DOI: 10.1113/ep091174.Commentaries, Editorials and LettersConceptsOral contraceptive pill useMicrovascular endothelial functionContraceptive pill useEndothelial functionCase reportPill useCessation
2022
Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis
Dillon GA, Stanhewicz AE, Serviente C, Flores VA, Stachenfeld N, Alexander LM. Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis. Microvascular Research 2022, 144: 104421. PMID: 35970408, PMCID: PMC9527706, DOI: 10.1016/j.mvr.2022.104421.Peer-Reviewed Original ResearchConceptsEndothelium-dependent vasodilationLaser Doppler fluxEndothelial functionCardiovascular diseaseOral atorvastatinExerts potent anti-inflammatory effectsEndothelium-dependent agonist acetylcholineShort-term statin administrationPotent anti-inflammatory effectsIntradermal microdialysis perfusionNO-dependent dilationImpaired endothelial functionMicrovascular endothelial functionCutaneous microvascular functionCutaneous vascular conductanceAnti-inflammatory effectsNO-dependent vasodilationNO synthase inhibitorDose-response curveStatin therapyAdjunctive therapyAtorvastatin treatmentCVD riskEndothelial dysfunctionStatin administration
2019
Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman CW, Yarovinsky T, Steele FE, Leone CA, Taylor HS, Bender JR, Stachenfeld NS. Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor. The Journal Of Physiology 2019, 597: 2853-2865. PMID: 30847930, DOI: 10.1113/jp277756.Peer-Reviewed Original ResearchMeSH KeywordsAdultAndrogensCardiovascular DiseasesDihydrotestosteroneEndothelin-1Endothelium, VascularEstrogensEthinyl EstradiolFemaleGlucose Tolerance TestHumansMicrovesselsNitric OxideObesityPolycystic Ovary SyndromeReceptor, Endothelin BSkinVascular Endothelial Growth Factor AVasodilationYoung AdultConceptsPolycystic ovary syndromeCardiovascular dysfunctionEndothelial dysfunctionOvary syndromeEndothelin-1Endothelial functionNO productionAndrogen receptor-dependent mannerEndothelin-B receptor subtypeCardiovascular risk factorsMicrovascular endothelial dysfunctionMicrovascular endothelial functionCutaneous vascular conductanceB receptor subtypesEndothelin B receptorLaser Doppler flowmetryNitric oxide inhibitionReceptor-dependent mannerEndothelial cell NO productionDose-response curveVasodilating responsePCOS subjectsLean womenObese womenVascular conductance
2017
Microvascular endothelial function in lean versus obese women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman C, Taylor H, Stachenfeld N. Microvascular endothelial function in lean versus obese women with polycystic ovary syndrome: role of the endothelin B receptor. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.691.5.Peer-Reviewed Original ResearchPolycystic ovary syndromeLean polycystic ovary syndromeObese PCOS womenCutaneous vascular conductanceNitric oxide inhibitionObese womenET-1PCOS womenOvary syndromeVasodilatory responseEndothelial functionOxide inhibitionEndothelin receptor subtype BObese polycystic ovary syndromeIntradermal microdialysis perfusionCardiovascular risk factorsMicrovascular endothelial functionPlasma endothelin-1Adverse cardiovascular outcomesAmerican Heart AssociationEndothelin B receptorLaser Doppler flowmetryDose-response curveCardiovascular outcomesIndependent vasodilation