2011
Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance
Wenner MM, Taylor HS, Stachenfeld NS. Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance. The Journal Of Physiology 2011, 589: 975-986. PMID: 21173076, PMCID: PMC3060374, DOI: 10.1113/jphysiol.2010.194563.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceHigh orthostatic toleranceOrthostatic toleranceAdrenergic responseAdrenergic responsivenessNitric oxide synthase inhibitor NG-monomethylEndogenous sex hormone productionSynthase inhibitor NG-monomethylSkin blood flow responseBlood flow responseInhibitor NG-monomethylSex hormone productionFemale sex hormonesLower body negative pressure testSkin blood flowGnRH antagonistProgesterone administrationOrthostatic intoleranceNG-monomethylPeripheral αMicrodialysis infusionSex hormonesCyclooxygenase pathwayHT womenAdrenergic control
2009
FEMALE REPRODUCTIVE HORMONE EFFECTS ON SKIN VESSEL ADRENERGIC RESPONSIVENESS IN WOMEN WITH LOW AND HIGH ORTHOSTATIC TOLERANCE.
Stachenfeld N, Hinds K, Taylor H. FEMALE REPRODUCTIVE HORMONE EFFECTS ON SKIN VESSEL ADRENERGIC RESPONSIVENESS IN WOMEN WITH LOW AND HIGH ORTHOSTATIC TOLERANCE. The FASEB Journal 2009, 23: 968.2-968.2. DOI: 10.1096/fasebj.23.1_supplement.968.2.Peer-Reviewed Original ResearchHigh orthostatic toleranceCumulative stress indexL-NMMAAdrenergic responsivenessOrthostatic toleranceLower body negative pressureReproductive hormone effectsNitric oxide mechanismBody negative pressureLaser Doppler flowmetrySkin blood flowStimulus-response curvesNorepinephrine infusionHormone antagonistDoppler flowmetryBlood flowDay 4Hormone effectsDay 13GnRHProgesteroneOxide mechanismWomenEstradiolResponsiveness