2009
Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia
Stachenfeld NS, Taylor HS. Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia. Journal Of Applied Physiology 2009, 107: 864-872. PMID: 19556454, DOI: 10.1152/japplphysiol.91211.2008.Peer-Reviewed Original ResearchConceptsExercise-associated hyponatremiaSodium lossGonadotropin-releasing hormone antagonistPeak oxygen consumptionMin of exerciseHistory of hyponatremiaHigh water intakeGnRH-antFluid retentionHormone antagonistProgesterone exposureEndurance exerciseDay 4Hormone effectsDay 13HyponatremiaSodium regulationHormone conditionsWomenHypoWater intakeOxygen consumptionProgesteroneExerciseLittle fall
2003
Oestrogen effects on urine concentrating response in young women
Stachenfeld NS, Taylor HS, Leone CA, Keefe DL. Oestrogen effects on urine concentrating response in young women. The Journal Of Physiology 2003, 552: 869-880. PMID: 12923212, PMCID: PMC2343447, DOI: 10.1113/jphysiol.2003.046920.Peer-Reviewed Original ResearchConceptsAVP infusionRenal sensitivityHormone treatmentDistal tubular sodium reabsorptionRenal free water clearanceRenal fluid retentionTubular sodium reabsorptionFree water clearancePlasma AVP concentrationArginine vasopressin releaseRate of clearancePhysiological rangeOE2 treatmentSodium excretionGnRHa administrationSodium reabsorptionEstrogen effectsEstrogen treatmentFluid retentionLeuprolide acetateWater clearanceRenal waterAVP concentrationVasopressin releaseUrine osmolality
2002
Estrogen effects on osmotic regulation of AVP and fluid balance
Stachenfeld NS, Keefe DL. Estrogen effects on osmotic regulation of AVP and fluid balance. AJP Endocrinology And Metabolism 2002, 283: e711-e721. PMID: 12217888, DOI: 10.1152/ajpendo.00192.2002.Peer-Reviewed Original ResearchConceptsHormone treatmentEstrogen effectsPlasma renin activityFree water clearanceEnd of recoveryIntrarenal effectsRenal sensitivityRenin activitySodium excretionFractional excretionAVP increaseSodium retentionFluid retentionLeuprolide acetateWater clearanceEndogenous estrogensAldosterone stimulationFluid balanceGnRHaNaCl infusionPg/EstrogenAVPProgesteroneExcretion
1999
Effects of oral contraceptives on body fluid regulation
Stachenfeld N, Silva C, Keefe D, Kokoszka C, Nadel E. Effects of oral contraceptives on body fluid regulation. Journal Of Applied Physiology 1999, 87: 1016-1025. PMID: 10484572, DOI: 10.1152/jappl.1999.87.3.1016.Peer-Reviewed Original ResearchConceptsBody fluid regulationLuteal phaseHighest plasma estradiol concentrationFluid regulationOral contraceptive administrationBody fluid retentionPlasma estradiol concentrationsMidluteal menstrual phasesBody fluid balanceArginine vasopressin concentrationBasal plasma osmolalityExercise dehydrationOral contraceptivesContraceptive administrationBody water balanceFluid retentionFollicular phaseEstradiol concentrationsAVP releaseMenstrual phaseFluid balanceVasopressin concentrationCrossover designThirst stimulationPlasma osmolality
1998
Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women
Stachenfeld N, Dipietro L, Palter S, Nadel E. Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women. American Journal Of Physiology 1998, 274: r187-r195. PMID: 9458917, DOI: 10.1152/ajpregu.1998.274.1.r187.Peer-Reviewed Original ResearchConceptsMin of drinkingPg/Body water balanceHypertonic salineFractional sodium excretionPlasma aldosterone concentrationRenal sodium reabsorptionFree water clearancePlasma estradiol concentrationsHypertonic saline infusionHigh E2 statesWater ad libitumMosmol/kgH2OAldosterone concentrationPostmenopausal womenSodium excretionPlacebo administrationUrine outputAVP secretionSodium reabsorptionFluid retentionE2 treatmentEstradiol concentrationsWater clearanceSaline infusion