ETA subtype receptor sensitivity to testosterone contributes to microvascular dysfunction in PCOS
Stachenfeld N, Wenner M, Taylor H. ETA subtype receptor sensitivity to testosterone contributes to microvascular dysfunction in PCOS. The FASEB Journal 2013, 27: 1133.10-1133.10. DOI: 10.1096/fasebj.27.1_supplement.1133.10.Peer-Reviewed Original ResearchPolycystic ovary syndromeCutaneous vascular conductanceHeat-induced vasodilationEndothelium-mediated vasodilationETB receptor antagonistLaser Doppler flowmetryETA blockadeTestosterone contributesEndothelial dysfunctionOvary syndromeVascular conductanceVasoconstrictor toneETA receptorsHormone antagonistReceptor antagonistMicrodialysis infusionSex hormonesDoppler flowmetryReceptor mechanismsReceptor sensitivityDay 8Day 4VasodilationDysfunctionAntagonist