2024
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Berbrier D, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia. AJP Heart And Circulatory Physiology 2024, 327: h140-h154. PMID: 38700469, DOI: 10.1152/ajpheart.00020.2024.Peer-Reviewed Original ResearchMuscle sympathetic nerve activitySystolic blood pressureResponse to acute stimuliIsometric handgrip exercise protocolMental stressHandgrip exercise protocolCardiovascular diseaseExercise-induced increaseEffective prevention strategiesAcute stimuliExercise protocolHistory of preeclampsiaBlood pressureIntegrated muscle sympathetic nerve activityElevated long-term riskElevated cardiovascular riskLong-term riskEnd-expiratory apneaSympathetic nerve activityPrevention strategiesHandgrip exerciseBlood pressure responseRisk factorsExaggerated pressorHealthy pregnancy
2022
Correlations between salivary- and blood-derived gonadal hormone assessments and implications for inclusion of female participants in research studies
Huang T, Howse F, Stachenfeld N, Usselman C. Correlations between salivary- and blood-derived gonadal hormone assessments and implications for inclusion of female participants in research studies. AJP Heart And Circulatory Physiology 2022, 324: h33-h46. PMID: 36426884, DOI: 10.1152/ajpheart.00399.2022.Peer-Reviewed Original ResearchConceptsMenstrual cycleGonadal hormonesFemale participantsVenous blood samplesGonadal hormone fluctuationsPrimary gonadalVascular functionBlood concentrationsCardiovascular diseaseHormone assessmentSerial measurementsHormone fluctuationsHormone monitoringBlood samplesStudy designGold standard measurementHuman physiology researchHormoneInclusion of femalesSalivaryResearch studiesCardiovascular researchersParticipantsFemalesSeven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis
Dillon GA, Stanhewicz AE, Serviente C, Flores VA, Stachenfeld N, Alexander LM. Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis. Microvascular Research 2022, 144: 104421. PMID: 35970408, PMCID: PMC9527706, DOI: 10.1016/j.mvr.2022.104421.Peer-Reviewed Original ResearchConceptsEndothelium-dependent vasodilationLaser Doppler fluxEndothelial functionCardiovascular diseaseOral atorvastatinExerts potent anti-inflammatory effectsEndothelium-dependent agonist acetylcholineShort-term statin administrationPotent anti-inflammatory effectsIntradermal microdialysis perfusionNO-dependent dilationImpaired endothelial functionMicrovascular endothelial functionCutaneous microvascular functionCutaneous vascular conductanceAnti-inflammatory effectsNO-dependent vasodilationNO synthase inhibitorDose-response curveStatin therapyAdjunctive therapyAtorvastatin treatmentCVD riskEndothelial dysfunctionStatin administrationSympathetic Responses to Isometric Handgrip Exercise in Women following Preeclamptic Pregnancies
Orr H, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Sympathetic Responses to Isometric Handgrip Exercise in Women following Preeclamptic Pregnancies. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r4218.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityPost-exercise circulatory occlusionHand-grip exerciseElevated muscle sympathetic nerve activityHP womenMSNA responsesPreeclamptic pregnanciesBaseline muscle sympathetic nerve activityIsometric hand-grip exerciseSympathetic nerve activityIsometric handgrip exerciseTotal peripheral resistanceHG exerciseSympathetic dysregulationCardiovascular outcomesCirculatory occlusionHandgrip exerciseArterial pressureHealthy pregnancyNerve activityPE pregnanciesPeripheral resistanceGrip exercisePE womenCardiovascular diseaseSubclinical cardiovascular disease and polycystic ovary syndrome
Gomez JMD, VanHise K, Stachenfeld N, Chan JL, Merz NB, Shufelt C. Subclinical cardiovascular disease and polycystic ovary syndrome. Fertility And Sterility 2022, 117: 912-923. PMID: 35512975, PMCID: PMC10322116, DOI: 10.1016/j.fertnstert.2022.02.028.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeSubclinical cardiovascular diseaseCardiovascular diseaseOvary syndromeCoronary artery calcium scoreCarotid intima-media thicknessOvert cardiovascular diseaseArtery calcium scoreFlow-mediated dilationIntima-media thicknessCalcium scoreDiabetes mellitusMetabolic syndromeArterial stiffnessIrregular mensesInsulin resistanceEpicardial fatMetabolic disordersVascular endotheliumSyndromeHallmark featureDiseaseWomenHyperandrogenismDyslipidemiaEndometriosis promotes atherosclerosis in a murine model
Mamillapalli R, Toffoloni N, Habata S, Qunhua H, Atwani R, Stachenfeld N, Taylor HS. Endometriosis promotes atherosclerosis in a murine model. American Journal Of Obstetrics And Gynecology 2022, 227: 248.e1-248.e8. PMID: 35351413, PMCID: PMC9308711, DOI: 10.1016/j.ajog.2022.03.040.Peer-Reviewed Original ResearchConceptsEffect of endometriosisOil Red O stainingVascular endothelial growth factorMurine modelCardiovascular diseaseRed O stainingEndothelial growth factorSham miceEndometriotic lesionsInflammatory cytokinesInterleukin-6Luminal areaInterferon gammaO stainingGrowth factorAortic luminal areasInflammatory-related cytokinesRoot wall thicknessUnderwent sham surgeryTreatment of endometriosisInflammation-related cytokinesDevelopment of atherosclerosisApolipoprotein E (ApoE<sup>-/-</sup>) miceLong-term riskWeeks of induction
2020
Autonomic Dysfunction in Women with Androgen Excess PCOS
Stone T, Leone C, Ayers T, Stachenfeld N. Autonomic Dysfunction in Women with Androgen Excess PCOS. The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.01846.Peer-Reviewed Original ResearchLower body negative pressurePolycystic ovary syndromeForearm vascular resistanceGnRH-antBlood pressureBaroreflex sensitivityEstrogen suppressionBRS slopeHormone suppressionAutonomic functionElevated blood pressureReproductive-age womenBody negative pressureTestosterone-induced changesAutonomic dysfunctionMild hypertensionVascular resistanceObese womenOvary syndromeGnRH antagonistAge womenBP regulationCardiovascular diseaseReproductive endocrinopathyBiochemical manifestationsA recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow
Usselman CW, Adler TE, Coovadia Y, Leone C, Paidas MJ, Stachenfeld NS. A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow. AJP Heart And Circulatory Physiology 2020, 318: h581-h589. PMID: 32004082, DOI: 10.1152/ajpheart.00578.2019.Peer-Reviewed Original ResearchConceptsMuscle sympathetic nerve activitySympathetic nerve activityArterial stiffnessBaroreflex sensitivityPreeclamptic womenUncomplicated pregnanciesNerve activityBlood pressureCardiovascular diseaseCentral pulse wave velocityCardiovagal baroreflex sensitivityElevated arterial stiffnessMuscle sympathetic outflowElevated cardiovascular riskHistory of preeclampsiaNormal blood pressurePeripheral arterial stiffnessSympathetic baroreflex sensitivitySympathetic nervous systemPulse wave velocityHigher MSNACardiovascular dysregulationSympathetic outflowCardiovascular riskNormal pregnancy
2019
Compromised endothelial function in transgender men taking testosterone
Stachenfeld N, Leone C, Gulanski B. Compromised endothelial function in transgender men taking testosterone. The FASEB Journal 2019, 33: 696.4-696.4. DOI: 10.1096/fasebj.2019.33.1_supplement.696.4.Peer-Reviewed Original ResearchEndothelial functionEndothelial dysfunctionBlood pressureTransgender menRisk factorsCisgender femalesCardiovascular risk factorsEarly follicular phaseSystolic blood pressureFull-text articlesTestosterone therapyAndrogen excessCardiovascular riskVasodilatory responseBlood lipidsHDL cholesterolSystolic BPLDL cholesterolCoronary arteryHormonal milieuFollicular phaseAndrogen treatmentMenstrual cycleCardiovascular diseaseAtherosclerotic plaques
2018
Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan
Stanhewicz AE, Wenner MM, Stachenfeld NS. Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan. AJP Heart And Circulatory Physiology 2018, 315: h1569-h1588. PMID: 30216121, PMCID: PMC6734083, DOI: 10.1152/ajpheart.00396.2018.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelial functionHealthy young womenCardiovascular diseaseVascular healthSex hormonesCardiovascular systemOverall cardiovascular disease riskSex differencesYoung womenAge-associated endothelial dysfunctionRenin-angiotensin systemPredictor of atherosclerosisAtherosclerotic cardiovascular diseaseCardiovascular disease riskCause of morbidityMale sex hormonesReceptor-independent mechanismVascular endothelinCVD riskEndothelial dysfunctionAge-related declineEarly decrementsFemale hormonesSimilar age-related declineCVD increasesBlood Pressure Predicts Endothelial Function and Effect of Ethinyl Estradiol in Young Obese and Lean Women
Adler T, Usselman C, Takamata A, Stachenfeld N. Blood Pressure Predicts Endothelial Function and Effect of Ethinyl Estradiol in Young Obese and Lean Women. The FASEB Journal 2018, 32: 713.3-713.3. DOI: 10.1096/fasebj.2018.32.1_supplement.713.3.Peer-Reviewed Original ResearchElevated blood pressureHigh blood pressureBlood pressureEndothelial functionEthinyl estradiol treatmentEndothelial dysfunctionFMD responseHealthy womenEstradiol treatmentAmerican Heart Association guidelinesNew American Heart Association guidelinesIschemic handgrip exerciseHeart Association guidelinesYoung healthy womenFull-text articlesShear stress stimulusRH-FMDMild hypertensionHandgrip exerciseLean womenVasodilatory responseHyperemic responseAssociation guidelinesCardiovascular diseaseEthinyl estradiolSympathetic Nervous System Reactivity in Women following Preeclamptic Pregnancies
Usselman C, Adler T, Leone C, Paidas M, Stachenfeld N. Sympathetic Nervous System Reactivity in Women following Preeclamptic Pregnancies. The FASEB Journal 2018, 32: 714.7-714.7. DOI: 10.1096/fasebj.2018.32.1_supplement.714.7.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityPreeclamptic pregnanciesWomen 6Cardiovascular diseaseBaseline muscle sympathetic nerve activitySympathetic nervous system dysregulationBaseline mean arterial pressureSympathetic nervous system responsesSympathetic nerve activityHistory of preeclampsiaMean arterial pressureTotal peripheral resistanceSympathetic nervous system reactivityChronic sympathetic activationDepartment of ObstetricsSympathetic nervous systemLife-long riskNervous system dysregulationNervous system responsesGreater sympathetic reactivityFull-text articlesChemoreflex stressMSNA responsesPreeclamptic womenArterial pressure
2016
The molecular actions of oestrogen in the regulation of vascular health
Usselman CW, Stachenfeld NS, Bender JR. The molecular actions of oestrogen in the regulation of vascular health. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2016, 101: 356-361. PMID: 26778523, PMCID: PMC4947570, DOI: 10.1113/ep085148.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAction of estrogenVascular healthFunctional outcomeHormone therapy trialsNormal endothelial functionVascular smooth muscleMembrane-bound estrogen receptorMolecular actionsPremenopausal womenEndothelial functionEstrogen actionCardiovascular diseaseEstrogen receptorSmooth muscleBeneficial actionsTherapy trialsEstrogenExperimental animalsVascular structuresFindings of studiesVasculatureWomenHealthMolecular mechanismsOutcomes
2010
Tissue Doppler of Early Mitral Filling Correlates With Simulated Volume Loss in Healthy Subjects
Moore CL, Tham ET, Samuels KJ, McNamara RL, Galante NJ, Stachenfeld N, Shelley K, Dziura J, Silverman DG. Tissue Doppler of Early Mitral Filling Correlates With Simulated Volume Loss in Healthy Subjects. Academic Emergency Medicine 2010, 17: 1162-1168. PMID: 21175513, DOI: 10.1111/j.1553-2712.2010.00906.x.Peer-Reviewed Original ResearchConceptsInferior vena cavaLBNP levelsTissue DopplerHealthy subjectsVital signsPulsed-wave tissue DopplerLower body negative pressureLateral mitral annulusEmergency department patientsTissue Doppler assessmentTissue Doppler velocitiesEarly diastolic fillingAccurate noninvasive assessmentPulsed-wave spectral DopplerLate transmitralNegative pressure levelBlood pressureDepartment patientsDoppler assessmentVena cavaDiastolic fillingVolume lossCardiovascular diseaseMitral annulusFilling wave