2023
Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome
Stone T, Yanes Cardozo L, Oluwatade T, Leone C, Burgos M, Okifo F, Pal L, Reckelhoff J, Stachenfeld N. Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome. AJP Heart And Circulatory Physiology 2023, 325: h232-h243. PMID: 37327000, PMCID: PMC10393337, DOI: 10.1152/ajpheart.00164.2023.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityBlood pressure dysregulationPolycystic ovary syndromeBody mass indexBaroreflex gainOvary syndromeBlood pressureObese insulin-resistant womenPolycystic ovary syndrome phenotypesRenin-angiotensin system activationSerum angiotensin-converting enzymeGonadotropin-releasing hormone antagonistLower sympathetic nervous system activityLower body negative pressureHeightened cardiovascular riskInsulin-resistant womenSystolic blood pressureBody negative pressureNervous system activityAngiotensin-converting enzymeIR womenCardiovascular riskSerum aldosteroneBaroreflex controlDiastolic BPEffects of androgen excess and body mass index on endothelial function in women with polycystic ovary syndrome
Berbrier D, Leone C, Adler T, Bender J, Taylor H, Stachenfeld N, Usselman C. Effects of androgen excess and body mass index on endothelial function in women with polycystic ovary syndrome. Journal Of Applied Physiology 2023, 134: 868-878. PMID: 36861670, DOI: 10.1152/japplphysiol.00583.2022.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeEndothelial dysfunctionEndothelial functionOvary syndromeAndrogen excessLean womenObese womenEstradiol supplementationLow flow-mediated constrictionOW/OB groupOverweight/obese womenMarked endothelial dysfunctionSevere endothelial dysfunctionFree testosterone levelsBody mass indexFlow-mediated dilation (FMD) testFree testosteroneMass indexReactive hyperemiaOB groupTestosterone levelsHealth differEndothelial pathophysiologyDysfunctionAndrogens
2017
Relationship between body mass index and endothelial dysfunction in women with and without polycystic ovary syndrome
Adler T, Usselman C, Anaeto L, Schapiro R, Steele F, Toffoloni N, Takamata A, Taylor H, Stachenfeld N. Relationship between body mass index and endothelial dysfunction in women with and without polycystic ovary syndrome. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.691.8.Peer-Reviewed Original ResearchPolycystic ovary syndromeEndothelial dysfunctionOvary syndromeFlow-mediated dilation responseSympathetic nervous system activationCardiovascular disease riskBody mass indexFlow-mediated dilation (FMD) testAmerican Heart AssociationMinutes of occlusionNervous system activationRotterdam criteriaFMD responseBrachial arteryEndothelial functionEndothelial healthHealthy womenHyperemic responseMass indexSuprasystolic pressureControl womenHeart AssociationInsulin resistanceClinical indicesReproductive age