2021
Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome
Nogueira R, Aries M, Minhas J, Petersen N, Xiong L, Kainerstorfer J, Castro P. Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 430-453. PMID: 34515547, PMCID: PMC8985432, DOI: 10.1177/0271678x211045222.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationAcute phaseClinical outcomesCerebral autoregulationAcute ischemic strokeCerebral hemodynamic parametersPotential therapeutic targetCerebrovascular disease statesAcute strokeIschemic strokeStroke onsetCerebral perfusionCerebral circulationIntracerebral hemorrhageHigh morbidityHemodynamic parametersIndividual patientsPerfusion interventionsNew therapiesTherapeutic targetHemodynamic aspectsPatientsAdditional treatmentDisease statesRelevant studies
2019
Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage
Silverman A, Kodali S, Strander S, Gilmore EJ, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth KN, Petersen NH. Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage. Stroke 2019, 50: 2729-2737. PMID: 31495332, PMCID: PMC6756936, DOI: 10.1161/strokeaha.119.026282.Peer-Reviewed Original ResearchConceptsLimits of autoregulationAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageFunctional outcomeArterial pressureIntracranial pressureBP targetsWorse outcomesPercent timeBlood pressure targetsBlood pressure managementMean arterial pressureModified Rankin ScalePotential neuroprotective strategiesWorse functional outcomePoor functional outcomeCerebral blood flowMultivariate logistic regressionTotal monitoring periodAutoregulatory indexPressure targetsCerebral ischemiaNeuroprotective strategiesRankin ScaleCerebral autoregulation
2015
Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke
Petersen NH, Ortega-Gutierrez S, Reccius A, Masurkar A, Huang A, Marshall RS. Dynamic Cerebral Autoregulation Is Transiently Impaired for One Week after Large-Vessel Acute Ischemic Stroke. Cerebrovascular Diseases 2015, 39: 144-150. PMID: 25661277, PMCID: PMC4754197, DOI: 10.1159/000368595.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationLarge-vessel ischemic strokeUnaffected hemisphereAffected hemisphereIschemic strokeCerebral autoregulationBlood pressureAcute large-vessel ischemic strokeLarge vessel acute ischemic strokeAcute blood pressure managementMiddle cerebral artery territoryAcute ischemic strokeBlood pressure managementCerebral blood flowBlood flow velocityDay strokePoor autoregulationAcute strokeArtery territoryArterial catheterTranscranial DopplerAffected sideUnaffected sideControl subjectsHealthy controls