2019
Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage
Silverman A, Kodali S, Strander S, Gilmore EJ, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth KN, Petersen NH. Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage. Stroke 2019, 50: 2729-2737. PMID: 31495332, PMCID: PMC6756936, DOI: 10.1161/strokeaha.119.026282.Peer-Reviewed Original ResearchConceptsLimits of autoregulationAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageFunctional outcomeArterial pressureIntracranial pressureBP targetsWorse outcomesPercent timeBlood pressure targetsBlood pressure managementMean arterial pressureModified Rankin ScalePotential neuroprotective strategiesWorse functional outcomePoor functional outcomeCerebral blood flowMultivariate logistic regressionTotal monitoring periodAutoregulatory indexPressure targetsCerebral ischemiaNeuroprotective strategiesRankin ScaleCerebral autoregulation
2017
Multimodality Monitoring
Cassa R, Petersen N. Multimodality Monitoring. 2017, 363-385. DOI: 10.1007/978-3-319-48669-7_20.Peer-Reviewed Original ResearchMultimodality monitoringBrain injuryJugular venous oxygen saturationAdditional brain injuryBrain tissue hypoxiaAcute brain injuryNon-convulsive seizuresVenous oxygen saturationBrain tissue oxygenationCerebral blood flowCerebral microdialysisQuantitative EEG measuresCerebral ischemiaIntracranial hypertensionSubclinical changesDelivery of oxygenVulnerable brainTissue hypoxiaIntracranial pressureOxygen saturationPathologic eventsBlood flowTissue oxygenationPhysiologic parametersMetabolic changes