2002
Hippocampal α7 and α4β2 nicotinic receptors and working memory
Levin E, Bradley A, Addy N, Sigurani N. Hippocampal α7 and α4β2 nicotinic receptors and working memory. Neuroscience 2002, 109: 757-765. PMID: 11927157, DOI: 10.1016/s0306-4522(01)00538-3.Peer-Reviewed Original ResearchConceptsDH beta EAlpha 7 nicotinic receptorAlpha 4 beta 2Ventral hippocampusNicotinic receptorsLow dosesBeta EReference memory errorsCounter-balanced orderRadial mazeHigh dosesAdult female Sprague-Dawley ratsFemale Sprague-Dawley ratsNicotine-induced memory improvementAcute intrahippocampal infusionsVentral hippocampal infusionsBeta 2Nicotinic receptor blockadeNicotinic receptor agonistsSprague-Dawley ratsΑ4β2 nicotinic receptorsSignificant increaseChronic guide cannulaeHippocampal α7Nicotinic involvement
2001
Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats
Levin E, Addy N, Nakajima A, Christopher N, Seidler F, Slotkin T. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Brain Research 2001, 130: 83-89. PMID: 11557096, DOI: 10.1016/s0165-3806(01)00215-2.Peer-Reviewed Original ResearchConceptsFigure-8 apparatusPostnatal CPF exposureCPF exposureEarly neonatal exposureMuscarinic cholinergic controlNeonatal chlorpyrifos exposurePersistent behavioral effectsRadial mazeT-mazeNicotinic cholinergic antagonistBrain cell developmentReference memory impairmentRadial arm mazeReference memory errorsPNDs 11Neonatal exposurePND 1Muscarinic antagonistNeonatal periodCholinergic antagonistsCholinergic controlNeurochemical changesRate of habituationCPF groupLong-term effects