Evaluating oral flavorant effects on nicotine self-administration behavior and phasic dopamine signaling
Wickham RJ, Nunes EJ, Hughley S, Silva P, Walton SN, Park J, Addy NA. Evaluating oral flavorant effects on nicotine self-administration behavior and phasic dopamine signaling. Neuropharmacology 2017, 128: 33-42. PMID: 28943284, PMCID: PMC5714675, DOI: 10.1016/j.neuropharm.2017.09.029.Peer-Reviewed Original ResearchConceptsSelf-administration behaviorNucleus accumbensNicotine self-administration behaviorIntravenous self-administration paradigmFast-scan cyclic voltammetryPublic health policy decisionsPhasic DA signalingTobacco product useProgressive ratio taskSelf-administration paradigmTwo-bottle choice testPhasic DA releaseHealth policy decisionsTobacco product regulationOral mentholOral nicotineOral sucroseNicotine administrationPreclinical findingsDA releaseMale ratsOral administrationSmoking behaviorNicotine aversionMenthol effects