2020
Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients
Spakowicz D, Lou S, Barron B, Gomez JL, Li T, Liu Q, Grant N, Yan X, Hoyd R, Weinstock G, Chupp GL, Gerstein M. Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients. Genome Biology 2020, 21: 150. PMID: 32571363, PMCID: PMC7310008, DOI: 10.1186/s13059-020-02033-z.Peer-Reviewed Original ResearchA Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma
Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. A Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 51-64. PMID: 32255668, PMCID: PMC7328332, DOI: 10.1164/rccm.201912-2360oc.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulum stressAirway inflammationNeutrophil countClinical featuresT-helper cell type 17Neutrophilic airway inflammationReticulum stressSputum of subjectsLung function impairmentHistory of hospitalizationNumber of neutrophilsPeripheral blood neutrophilsSputum of patientsMicroRNA expressionAsthma severityTh17 pathwayFunction impairmentAirway samplesMicroRNA networkBlood neutrophilsOzone exposureAsthmaSputumCellular sourceClinical phenotype
2018
Building an Informed Consent Tool Starting with the Patient: The Patient-Centered Virtual Multimedia Interactive Informed Consent (VIC).
Abujarad F, Alfano S, Bright TJ, Kannoth S, Grant N, Gueble M, Peduzzi P, Chupp G. Building an Informed Consent Tool Starting with the Patient: The Patient-Centered Virtual Multimedia Interactive Informed Consent (VIC). AMIA Annual Symposium Proceedings 2018, 2017: 374-383. PMID: 29854101, PMCID: PMC5977640.Peer-Reviewed Original Research
2016
MAPKAP kinase 2(MK2) expression is associated with severe asthma
Chupp G, Yan X, Nezgovorova V, Grant N, Bradford W, Brophy C, Cohn L. MAPKAP kinase 2(MK2) expression is associated with severe asthma. 2016, pa4649. DOI: 10.1183/13993003.congress-2016.pa4649.Peer-Reviewed Original ResearchProinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroups
Gueble M, Holm C, Grant N, Ravage-Mass L, Levesh T, Estrom J, Kapagiannidou E, Liu Q, O'Connor P, Gomez-Villalobos J, Cohn L, Chupp G. Proinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroups. 2016, pa908. DOI: 10.1183/13993003.congress-2016.pa908.Peer-Reviewed Original ResearchSputum Gene Expression of IL-13 Receptor α2 Chain Correlates with Airflow Obstruction and Helper T-Cell Type 2 Inflammation in Asthma
Nezgovorova V, Liu Q, Hu B, Villalobos JL, Yan X, Niu N, Holm C, Grant NP, Marone S, Ravage-Mass L, Lee CG, Elias JA, Cohn L, Chupp GL. Sputum Gene Expression of IL-13 Receptor α2 Chain Correlates with Airflow Obstruction and Helper T-Cell Type 2 Inflammation in Asthma. Annals Of The American Thoracic Society 2016, 13 Suppl 1: s96-7. PMID: 27027964, PMCID: PMC5015742, DOI: 10.1513/annalsats.201509-611mg.Peer-Reviewed Original Research