2012
Bupropion pre-treatment of endotoxin-induced depressive symptoms
DellaGioia N, Devine L, Pittman B, Hannestad J. Bupropion pre-treatment of endotoxin-induced depressive symptoms. Brain Behavior And Immunity 2012, 31: 197-204. PMID: 23064079, DOI: 10.1016/j.bbi.2012.10.008.Peer-Reviewed Original ResearchConceptsVisual analog scaleInflammatory cytokinesDepressive symptomsSerum levelsMontgomery-Åsberg Depression Rating ScaleSerotonin reuptake inhibitor citalopramLow-dose lipopolysaccharideReuptake inhibitor citalopramCross-over studyDepression Rating ScaleTotal MADRS scoreDopamine reuptake inhibitorInnate immune responseInnate immune systemIntravenous LPSLPS administrationReuptake inhibitorsAnalog scaleMADRS scoresHealthy subjectsImmune responseBupropionImmune systemCytokinesLPSGlucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans
Hannestad J, Subramanyam K, Dellagioia N, Planeta-Wilson B, Weinzimmer D, Pittman B, Carson RE. Glucose Metabolism in the Insula and Cingulate Is Affected by Systemic Inflammation in Humans. Journal Of Nuclear Medicine 2012, 53: 601-607. PMID: 22414635, PMCID: PMC3717572, DOI: 10.2967/jnumed.111.097014.Peer-Reviewed Original ResearchConceptsNormalized glucose metabolismMontgomery-Åsberg Depression Rating ScalePeak cytokine levelsSystemic inflammationDepression Rating ScaleDepressive symptomsGlucose metabolismCytokine levelsFDG-PETRating ScaleSystemic inflammatory responseCerebral metabolic rateMild depressive symptomsRight anterior cingulateTumor necrosis factorRight anterior insulaSerum levelsInflammatory cytokinesEndotoxin administrationInterleukin-6Inflammatory responseNecrosis factorCingulate subregionsHealthy subjectsInflammation
2011
The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis
Hannestad J, DellaGioia N, Bloch M. The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis. Neuropsychopharmacology 2011, 36: 2452-2459. PMID: 21796103, PMCID: PMC3194072, DOI: 10.1038/npp.2011.132.Peer-Reviewed Original ResearchConceptsMajor depressive disorderInflammatory cytokinesSerum levelsAntidepressant treatmentInterleukin-6Depressive symptomsIL-1βCytokine levelsDepressive episodeDiagnosis of MDDTumor necrosis factor alphaPharmacological antidepressant treatmentAntidepressant medication treatmentClasses of antidepressantsStratified subgroup analysisIL-1 betaNecrosis factor alphaNormalization of levelsReuptake inhibitorsMedication treatmentPharmacological treatmentSubgroup analysisBrain dysfunctionDepressive disorderFactor alpha
2010
Citalopram reduces endotoxin-induced fatigue
Hannestad J, DellaGioia N, Ortiz N, Pittman B, Bhagwagar Z. Citalopram reduces endotoxin-induced fatigue. Brain Behavior And Immunity 2010, 25: 256-259. PMID: 20955776, PMCID: PMC3025065, DOI: 10.1016/j.bbi.2010.10.013.Peer-Reviewed Original ResearchConceptsTumor necrosis factorMADRS total scoreDepressive-like symptomsInterleukin-6Serum levelsImmune responseMontgomery-Åsberg Depression Rating ScaleTotal scorePeripheral immune responseLow-dose endotoxinCross-over studyVisual analog scaleDepression Rating ScaleImmune system activationInnate immune responseInnate immune systemEffect sizeTrait Anxiety InventoryModerate effect sizeAnalog scaleInflammatory cytokinesEndotoxin administrationPreventive treatmentNecrosis factorHealthy subjects
2009
A critical review of human endotoxin administration as an experimental paradigm of depression
DellaGioia N, Hannestad J. A critical review of human endotoxin administration as an experimental paradigm of depression. Neuroscience & Biobehavioral Reviews 2009, 34: 130-143. PMID: 19666048, PMCID: PMC2795398, DOI: 10.1016/j.neubiorev.2009.07.014.Peer-Reviewed Original ResearchConceptsImmune system activationEndotoxin administrationSystem activationImmune stimuliDepressive symptomsInnate immune system activationElicit depressive symptomsInterferon-alpha treatmentCommon final pathwayPotential molecular pathwaysImmunologic abnormalitiesImmune depressionVaccine administrationInflammatory cytokinesDepression paradigmDepressed patientsFinal pathwaySymptomsDepression researchAdministrationDepressionMolecular pathwaysBehavioral changesActivationRodents