2017
Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?
Tricò D, Di Sessa A, Caprio S, Chalasani N, Liu W, Liang T, Graf J, Herzog R, Johnson CD, Umano GR, Feldstein AE, Santoro N. Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota? Antioxidants & Redox Signaling 2017, 30: 241-250. PMID: 28279074, PMCID: PMC6277079, DOI: 10.1089/ars.2017.7049.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsBiomarkersChildDelta-5 Fatty Acid DesaturaseDisease SusceptibilityFatty Acid DesaturasesFemaleGastrointestinal MicrobiomeGenetic BackgroundGenetic Predisposition to DiseaseHaplotypesHumansLinoleic AcidLipid MetabolismLipoproteinsMaleMetabolic SyndromeMetabolomeObesityOxidation-ReductionConceptsProatherogenic lipoprotein profilePediatric metabolic syndromeLipoprotein profileGut microbiotaGut bacterial loadMetabolic syndromeObese adolescentsSmall dense low-density lipoproteinBacterial loadAdverse lipoprotein profileLow-density lipoprotein particlesHigher plasma concentrationsLow-density lipoproteinLinoleic acid metabolitesPlasma 9Haplotype AAPathogenic rolePlasma concentrationsGenetic predispositionAcid metabolitesGenetic backgroundLipoprotein particlesMetSSyndromeMicrobiota
2016
Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study
Goffredo M, Caprio S, Feldstein AE, D'Adamo E, Shaw MM, Pierpont B, Savoye M, Zhao H, Bale AE, Santoro N. Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study. Hepatology 2016, 63: 117-125. PMID: 26457389, PMCID: PMC4688225, DOI: 10.1002/hep.28283.Peer-Reviewed Original ResearchConceptsFatty liver diseaseHepatic fat contentLiver diseaseLiver biopsyTM6SF2 rs58542926Nonalcoholic fatty liver disease activity scorePediatric nonalcoholic fatty liver diseaseHigh hepatic fat contentPediatric fatty liver diseaseHigher alanine aminotransferase levelsNonalcoholic fatty liver diseaseOral glucose tolerance testMinor alleleDisease Activity ScoreIntrahepatic fat accumulationUnderwent liver biopsyAlanine aminotransferase levelsFavorable lipoprotein profileGlucose tolerance testLiver panelAminotransferase levelsCardiovascular riskActivity scoreObese childrenLipoprotein profile