2023
Association between age at menarche and cardiometabolic risk among Samoan adults
Oyama S, Duckham R, Pomer A, Rivara A, Kershaw E, Wood A, Fidow U, Naseri T, Reupena M, Viali S, McGarvey S, Hawley N. Association between age at menarche and cardiometabolic risk among Samoan adults. American Journal Of Human Biology 2023, 36: e23982. PMID: 37668413, PMCID: PMC10845161, DOI: 10.1002/ajhb.23982.Peer-Reviewed Original ResearchConceptsCardiometabolic riskOne-year increaseSubsequent cardiometabolic riskOdds of hypertensionHigher total cholesterolOdds of diabetesOdds of obesityEarly life exposureFat-free massCardiometabolic morbiditySerum lipidsBlood pressureMedian ageMetabolic syndromeTotal cholesterolProspective studyChildhood adiposityInsulin resistanceObesity prevalenceLife exposureSamoan adultsLean massEarly menarcheLogistic regressionMenarche
2022
The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans
Hawley NL, Duckham RL, Carlson JC, Naseri T, Reupena MS, Lameko V, Pomer A, Wetzel A, Selu M, Lupematisila V, Unasa F, Vesi L, Fatu T, Unasa S, Faasalele‐Savusa K, Rivara AC, Russell E, Delany JP, Viali S, Kershaw EE, Minster RL, Weeks DE, McGarvey ST. The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans. Obesity 2022, 30: 2468-2476. PMID: 36284436, PMCID: PMC10111239, DOI: 10.1002/oby.23559.Peer-Reviewed Original ResearchConceptsFat-free massType 2 diabetesFat distributionProtective effectBody compositionFavorable body fat distributionDual-energy X-ray absorptiometry-derived body compositionBody fat distributionGreater fat-free massPercent body fatBody size/compositionAssociation of genotypesRs373863828 genotypeVisceral adiposityHigher BMIAdult SamoansRole of fatGreater BMILean massBody fatLower oddsParadoxical associationTissue-specific mechanismsA alleleDiabetes
2020
A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
Arslanian KJ, Fidow UT, Atanoa T, Unasa-Apelu F, Naseri T, Wetzel AI, Pomer A, Duckham RL, McGarvey ST, Strayer JA, Kershaw EE, Weeks DE, Hawley NL. A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants. International Journal Of Obesity 2020, 45: 45-55. PMID: 32884101, PMCID: PMC8329753, DOI: 10.1038/s41366-020-00659-4.Peer-Reviewed Original ResearchConceptsBody mass indexDual-energy X-ray absorptiometrySamoan infantsBone massFat massLean massEarly infantsBody compositionInfant body mass indexMinor alleleDeterminants of adiposityOdds of diabetesBone mass accretionMissense variantsX-ray absorptiometryFat-free massCross-sectional analysisMore bone massCREBRF variantProspective studyHigher oddsEarly infancyInfantsAdult populationNatural history