2020
The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis
Pokorzynski ND, Hatch ND, Ouellette SP, Carabeo RA. The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis. Nature Communications 2020, 11: 6430. PMID: 33353937, PMCID: PMC7755916, DOI: 10.1038/s41467-020-20181-5.Peer-Reviewed Original ResearchConceptsIntergenic regionRho-independent transcription terminationOpen reading frameTranscription terminationYtgRAlternative promotersTrp operonOperator sequenceTryptophan limitationOperonMajor promoterModel bacteriaTrpRSPromoterMotifBacteriaExpressionChlamydia trachomatisRepressorTrpBRepressionFundamental importanceTRPLAlternative strategySequence
2019
A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis
Pokorzynski ND, Brinkworth AJ, Carabeo R. A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis. ELife 2019, 8: e42295. PMID: 30938288, PMCID: PMC6504234, DOI: 10.7554/elife.42295.Peer-Reviewed Original ResearchConceptsSalvage pathwayNovel promoter elementIron-dependent regulationStress response regulatorGlobal stress response regulatorIron-dependent regulatorTermination of transcriptsIntergenic region upstreamHost immune effectorsResponse regulatorTranscriptional regulationObligate intracellular bacteriumIron starvationIntergenic regionPromoter elementsPromoter upstreamTryptophan biosynthesisStress responseRegion upstreamIron-dependent mechanismEssential nutrientsIntracellular bacteriumChlamydia trachomatisImmune effectorsRegulation