IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans
Mar J, Ota N, Pokorzynski N, Peng Y, Jaochico A, Sangaraju D, Skippington E, Lekkerkerker A, Rothenberg M, Tan M, Yi T, Keir M. IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans. Microbiome 2023, 11: 47. PMID: 36894983, PMCID: PMC9997005, DOI: 10.1186/s40168-023-01486-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGastrointestinal MicrobiomeHumansIndolesInterleukinsMiceReceptors, Aryl HydrocarbonConceptsIL-22 treatmentUC patientsAhR activityIL-22 productionUlcerative colitis patientsGastrointestinal barrier functionMicrobiome compositionGut microbiome compositionAryl hydrocarbon receptorColitis patientsIL-22Gastrointestinal tractHealthy volunteersFunctional capacityMucus secretionAntimicrobial protein productionMicrobiota compositionEpithelial cell differentiationFecal concentrationsReceptor activityGut microbiomePatientsAhR signalingAryl hydrocarbon receptor (AhR) activityBarrier function