2022
Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis
Pokorzynski N, Alla M, Carabeo R. Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis. MBio 2022, 13: e02719-22. PMID: 36377897, PMCID: PMC9765610, DOI: 10.1128/mbio.02719-22.Peer-Reviewed Original ResearchConceptsHost cell responsesInfected host cellsNutritional stressStress responseIntracellular environmentGTP biosynthesisHost cellsUniversal stress responseTranscriptional stress responseDual RNA sequencingConsequence of coevolutionEssential nutrient ironBacterial stress responseStress response mechanismsChlamydial growthGuanine nucleotide synthesisGenome reductionTryptophan starvationEukaryotic hostsIron starvationInfected epithelial cellsRNA sequencingNutrient ironIron limitationDistinct nutrients
2017
Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia
Pokorzynski ND, Thompson CC, Carabeo RA. Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia. Frontiers In Cellular And Infection Microbiology 2017, 7: 394. PMID: 28951853, PMCID: PMC5599777, DOI: 10.3389/fcimb.2017.00394.Peer-Reviewed Original ResearchConceptsGene regulationIron homeostasisAberrant morphological phenotypesIron biologyUnconventional mechanismObligate intracellular pathogensDeprivation of ironSpecies relativesTranscriptional regulatorsGenome sequenceTransporter subunitsIron acquisitionIron-dependent bacteriaVesicular modeChlamydial speciesMorphological phenotypesIntracellular environmentIntracellular pathogensImportance of ironRecent discoveryAvailability of ironHomeostasisRecent findingsBiologyPersistent phenotype