Bacteria require phase separation for fitness in the mammalian gut
Krypotou E, Townsend G, Gao X, Tachiyama S, Liu J, Pokorzynski N, Goodman A, Groisman E. Bacteria require phase separation for fitness in the mammalian gut. Science 2023, 379: 1149-1156. PMID: 36927025, PMCID: PMC10148683, DOI: 10.1126/science.abn7229.Peer-Reviewed Original ResearchConceptsMammalian gutTranscription termination factor RhoTermination factor RhoGene regulationTranscription terminationMechanisms bacteriaBacteria interactionsHuman commensalValuable targetBacteriaRhoGut microbiotaFitnessNovel clinical applicationsTherapeutic manipulationGutHuman healthCommensalRegulationIL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans
Mar J, Ota N, Pokorzynski N, Peng Y, Jaochico A, Sangaraju D, Skippington E, Lekkerkerker A, Rothenberg M, Tan M, Yi T, Keir M. IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans. Microbiome 2023, 11: 47. PMID: 36894983, PMCID: PMC9997005, DOI: 10.1186/s40168-023-01486-1.Peer-Reviewed Original ResearchConceptsIL-22 treatmentUC patientsAhR activityIL-22 productionUlcerative colitis patientsGastrointestinal barrier functionMicrobiome compositionGut microbiome compositionAryl hydrocarbon receptorColitis patientsIL-22Gastrointestinal tractHealthy volunteersFunctional capacityMucus secretionAntimicrobial protein productionMicrobiota compositionEpithelial cell differentiationFecal concentrationsReceptor activityGut microbiomePatientsAhR signalingAryl hydrocarbon receptor (AhR) activityBarrier function