2022
Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis
Pokorzynski N, Alla M, Carabeo R. Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis. MBio 2022, 13: e02719-22. PMID: 36377897, PMCID: PMC9765610, DOI: 10.1128/mbio.02719-22.Peer-Reviewed Original ResearchConceptsHost cell responsesInfected host cellsNutritional stressStress responseIntracellular environmentGTP biosynthesisHost cellsUniversal stress responseTranscriptional stress responseDual RNA sequencingConsequence of coevolutionEssential nutrient ironBacterial stress responseStress response mechanismsChlamydial growthGuanine nucleotide synthesisGenome reductionTryptophan starvationEukaryotic hostsIron starvationInfected epithelial cellsRNA sequencingNutrient ironIron limitationDistinct nutrients
2019
A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis
Pokorzynski ND, Brinkworth AJ, Carabeo R. A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis. ELife 2019, 8: e42295. PMID: 30938288, PMCID: PMC6504234, DOI: 10.7554/elife.42295.Peer-Reviewed Original ResearchConceptsSalvage pathwayNovel promoter elementIron-dependent regulationStress response regulatorGlobal stress response regulatorIron-dependent regulatorTermination of transcriptsIntergenic region upstreamHost immune effectorsResponse regulatorTranscriptional regulationObligate intracellular bacteriumIron starvationIntergenic regionPromoter elementsPromoter upstreamTryptophan biosynthesisStress responseRegion upstreamIron-dependent mechanismEssential nutrientsIntracellular bacteriumChlamydia trachomatisImmune effectorsRegulation