2022
Design and Basic Characteristics of a National Patient-Powered Registry in ADPKD
Hoover E, Perrone RD, Rusconi C, Benson B, Dahl NK, Gitomer B, Manelli A, Mrug M, Park M, Seliger SL, Phadnis MA, Thewarapperuma N, Watnick TJ. Design and Basic Characteristics of a National Patient-Powered Registry in ADPKD. Kidney360 2022, 3: 1350-1358. PMID: 36176661, PMCID: PMC9416821, DOI: 10.34067/kid.0002372022.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseKidney diseaseCore questionnaireManagement of ADPKDPatient-reported diagnosisPost-kidney transplantHealth-related qualityPatient-centered outcomesDominant polycystic kidney diseaseQuality of lifePolycystic kidney diseaseHispanics/LatinosCKD stageKidney transplantMedian ageKidney functionNational PatientBurden scoreDisease stageExtrarenal manifestationsPatient enrollmentADPKD patientsCreatinine valuesClinical trialsClinical studies
2021
Association of AKI-D with Urinary Findings and Baseline eGFR in Hospitalized COVID-19 Patients
Patel DM, Phadke M, Dai F, Simonov M, Dahl NK, Kodali R. Association of AKI-D with Urinary Findings and Baseline eGFR in Hospitalized COVID-19 Patients. Kidney360 2021, 2: 1215-1224. PMID: 35369662, PMCID: PMC8676386, DOI: 10.34067/kid.0001612021.Peer-Reviewed Original ResearchConceptsOdds of AKIBaseline eGFRLower oddsHospital AKIInitial urinalysisHospital deathRisk factorsHospitalized COVID-19 patientsActive urine sedimentAssociation of AKIBaseline kidney functionHigher baseline eGFRCongestive heart failureCOVID-19 patientsCoronavirus disease 2019COVID-19Electronic health recordsAKI statusUrinary findingsInflammatory markersUrinalysis findingsHeart failurePatient characteristicsKidney functionDisease 2019
2019
Intraoperative Ultrasound Guidance for Banding of an Arteriovenous Fistula Causing High Cardiac Output Heart Failure
Turner AD, Chen M, Dahl N, Scoutt L, Dardik A, Ochoa Chaar C. Intraoperative Ultrasound Guidance for Banding of an Arteriovenous Fistula Causing High Cardiac Output Heart Failure. Annals Of Vascular Surgery 2019, 66: 665.e5-665.e8. PMID: 31863947, DOI: 10.1016/j.avsg.2019.12.011.Peer-Reviewed Case Reports and Technical NotesConceptsEnd-stage renal diseaseArteriovenous fistulaHigh cardiac output heart failureHigh cardiac output failureHigh-output cardiac failureOutput cardiac failureIntraoperative ultrasound guidanceRare complicationCardiac failureHeart failureRenal diseaseCase reportCardiac functionUltrasound guidanceIntraoperative ultrasoundFlow volumeOutput failureFistulaPatientsGradual declineFailureBandingComplicationsHemodialysisHigh flow volumesRisk factors and safe contrast volume thresholds for postcontrast acute kidney injury after peripheral vascular interventions
Lee SR, Zhuo H, Zhang Y, Dahl N, Dardik A, Ochoa Chaar CI. Risk factors and safe contrast volume thresholds for postcontrast acute kidney injury after peripheral vascular interventions. Journal Of Vascular Surgery 2019, 72: 603-610.e1. PMID: 31843298, DOI: 10.1016/j.jvs.2019.09.059.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedCanadaContrast MediaDatabases, FactualEndovascular ProceduresFemaleHumansIncidenceKidneyMaleMiddle AgedPatient SafetyPeripheral Arterial DiseaseRadiography, InterventionalRenal Insufficiency, ChronicRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeUnited StatesConceptsAdvanced chronic kidney diseaseChronic kidney diseasePeripheral vascular interventionsStages of CKDPostcontrast acute kidney injuryBaseline kidney functionPC-AKIAcute kidney injuryContrast volumeVolume of contrastRisk factorsKidney injuryCumulative incidenceLimb ischemiaKidney functionVascular interventionsMultivariable Cox proportional hazards regressionCox proportional hazards regressionAcute limb ischemiaLong-term mortalityCritical limb ischemiaNormal kidney functionMultivariable logistic regressionProportional hazards regressionLong-term survivalInherited glomerular diseases in the gilded age of genomic advancements
Gulati A, Dahl N, Tufro A. Inherited glomerular diseases in the gilded age of genomic advancements. Pediatric Nephrology 2019, 35: 959-968. PMID: 31049720, PMCID: PMC7184048, DOI: 10.1007/s00467-019-04266-y.Peer-Reviewed Original ResearchConceptsGenomic advancementsHigh-throughput next-generation sequencing technologiesNext-generation sequencing technologiesSingle nucleotide changeSingle nucleotide variationsDisease-causing mutationsDNA variationHuman genomeNext-generation sequencingGenomic informationSequencing technologiesNucleotide variationsAccurate genetic diagnosisNucleotide changesGenetic diagnosisSmall insertionsGenomic knowledgeCytogenetic methodsBiological interpretationMutation spectrumSequencingGenomic medicineGenomeUncertain significanceGlomerular disease
2018
A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan
Chebib FT, Perrone RD, Chapman AB, Dahl NK, Harris PC, Mrug M, Mustafa RA, Rastogi A, Watnick T, Yu ASL, Torres VE. A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan. Journal Of The American Society Of Nephrology 2018, 29: 2458-2470. PMID: 30228150, PMCID: PMC6171265, DOI: 10.1681/asn.2018060590.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseOpen-label extension studyProgressive autosomal dominant polycystic kidney diseaseFirst drug treatmentRenal protective measuresKidney function declineLiver enzyme elevationCare of patientsConfirmation of diagnosisEducation of patientsCounseling of patientsDominant polycystic kidney diseasePolycystic kidney diseaseTolvaptan treatmentProgressive diseaseEnzyme elevationFunction declineKidney diseaseClinical trialsGeneral practitionersDrug treatmentTreatment efficacyPatientsTolvaptanUS FoodQuantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring
Rauniyar N, Yu X, Cantley J, Voss EZ, Belcher J, Colangelo CM, Stone KL, Dahl N, Parikh C, Lam TT, Cantley LG. Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring. Proteomics Clinical Applications 2018, 12: e1700157. PMID: 29573172, PMCID: PMC6736530, DOI: 10.1002/prca.201700157.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseasePolycystic kidney diseaseCyst growthKidney diseaseUrinary proteinNormal controlsEnd-stage renal failureUrine samplesUrinary protein biomarkersLife-long diseasePresence of cystsRespective urine samplesMost patientsRenal failureADPKD patientsEarly diagnosisClinical relevanceUrinary proteomeParallel reaction monitoringPatientsCyst formationDiseaseWater intakePathogenesisPreimplantation Genetic Diagnosis Counseling in Autosomal Dominant Polycystic Kidney Disease
Murphy EL, Droher ML, DiMaio MS, Dahl NK. Preimplantation Genetic Diagnosis Counseling in Autosomal Dominant Polycystic Kidney Disease. American Journal Of Kidney Diseases 2018, 72: 866-872. PMID: 29606500, DOI: 10.1053/j.ajkd.2018.01.048.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseaseKidney diseasePolycystic kidney diseasePreimplantation genetic diagnosisDisease burdenHeight-adjusted total kidney volumeChronic kidney diseaseSignificant disease burdenAge 35 yearsTotal kidney volumeCommon hereditary formAssisted Reproductive TechnologyFluid-filled cystsRenal diseaseHepatic cystsKidney volumeFamily historyHigh riskHereditary formsIntracranial aneurysmsGenetic testingEarly onsetUrologic eventsSemaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment
Lee Y, Blount KL, Dai F, Thompson S, Scher JK, Bitterman S, Droher M, Herzog EL, Moeckel G, Karihaloo A, Dahl NK. Semaphorin 7A in circulating regulatory T cells is increased in autosomal-dominant polycystic kidney disease and decreases with tolvaptan treatment. Clinical And Experimental Nephrology 2018, 22: 906-916. PMID: 29453607, DOI: 10.1007/s10157-018-1542-x.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAutosomal dominant polycystic kidney diseaseEnd-stage renal diseaseRenal fibrosisSEMA7A expressionADPKD patientsTolvaptan treatmentPolycystic kidney diseaseKidney diseaseNumber of PBMCsExpression of SEMA7ASubsequent renal fibrosisMarkers of inflammationRegulatory T cellsADPKD kidneysBlood mononuclear cellsImmunomodulating proteinsRenal diseaseMononuclear cellsSmall kidneysKidney fibrosisLiver fibrosisRenal cystsSemaphorin 7AT cells
2016
Simple Renal Cysts as Markers of Thoracic Aortic Disease
Ziganshin BA, Theodoropoulos P, Salloum MN, Zaza KJ, Tranquilli M, Mojibian HR, Dahl NK, Fang H, Rizzo JA, Elefteriades JA. Simple Renal Cysts as Markers of Thoracic Aortic Disease. Journal Of The American Heart Association 2016, 5: e002248. PMID: 26746998, PMCID: PMC4859353, DOI: 10.1161/jaha.115.002248.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAgedAged, 80 and overAortic Aneurysm, ThoracicAortic DissectionAortographyConnecticutFemaleHumansKidney Diseases, CysticMagnetic Resonance AngiographyMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsSex DistributionTomography, X-Ray ComputedYoung AdultConceptsPrevalence of SRCThoracic aortic diseaseSimple renal cystsAortic aneurysmAortic dissectionControl groupAortic diseaseRenal cystsPresence of SRCType B aortic dissectionAortic disease patientsType B dissectionAbdominal computed tomographyB aortic dissectionAbdominal aortic aneurysmMagnetic resonance imagingB dissectionMale predominanceDisease patientsSilent diseaseClinical markersComputed tomographyPatientsAneurysmsResonance imaging
2015
Effect of the decrease in dialysate sodium in pediatric patients on chronic hemodialysis
Marsenic O, Anderson M, Couloures KG, Hong WS, Hall E, Dahl N. Effect of the decrease in dialysate sodium in pediatric patients on chronic hemodialysis. Hemodialysis International 2015, 20: 277-285. PMID: 26663617, DOI: 10.1111/hdi.12384.Peer-Reviewed Original ResearchConceptsPediatric patientsDialysate sodiumPediatric HD populationPediatric hemodialysis populationStandard HD sessionInterdialytic weight gainMEq/LChronic HDHemodialysis populationChronic hemodialysisHD sessionHD populationInterdialytic periodAdult studiesPatientsWeight gainStudy periodLack of concordanceFurther studiesSodium gradientFirst reportHypertensionPredialysisHemodialysisPopulationTotal Kidney Volume in Autosomal Dominant Polycystic Kidney Disease: A Biomarker of Disease Progression and Therapeutic Efficacy
Alam A, Dahl NK, Lipschutz JH, Rossetti S, Smith P, Sapir D, Weinstein J, McFarlane P, Bichet DG. Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease: A Biomarker of Disease Progression and Therapeutic Efficacy. American Journal Of Kidney Diseases 2015, 66: 564-576. PMID: 25960302, DOI: 10.1053/j.ajkd.2015.01.030.Peer-Reviewed Original ResearchConceptsTotal kidney volumeAutosomal dominant polycystic kidney diseaseDisease progressionKidney enlargementKidney functionClinical trialsKidney volumeEnd pointAutosomal dominant polycystic kidneyKidney function measuresPrognostic end pointProgressive kidney enlargementEfficacy end pointGlomerular filtration rateDominant polycystic kidney diseasePolycystic kidney diseaseFluid-filled cystsKidney diseaseFiltration rateCurrent evidencePolycystic kidneysCyst growthFibrotic tissueTherapeutic efficacyTherapeutic interventions
2014
CT Urography for the Diagnosis of Medullary Sponge Kidney
Koraishy FM, Ngo TT, Israel GM, Dahl NK. CT Urography for the Diagnosis of Medullary Sponge Kidney. American Journal Of Nephrology 2014, 39: 165-170. PMID: 24531190, DOI: 10.1159/000358496.Peer-Reviewed Original ResearchConceptsMedullary sponge kidneyCharacteristic radiologic findingsIntravenous pyelographyCT urographySponge kidneyRadiologic findingsMultidetector CTDiagnosis of MSKRenal acidification defectsUrinary tract infectionRisk of nephrolithiasisRenal stones clinicDose reduction protocolTerminal collecting ductsConventional intravenous pyelographyRenal collecting systemTubule dilatationMedullary nephrocalcinosisStone clinicTract infectionsSymptomatic nephrolithiasisMedullary cystsBone densityAcidification defectCollecting ducts
2012
Evaluation of urine biomarkers of kidney injury in polycystic kidney disease
Parikh CR, Dahl NK, Chapman AB, Bost JE, Edelstein CL, Comer DM, Zeltner R, Tian X, Grantham JJ, Somlo S. Evaluation of urine biomarkers of kidney injury in polycystic kidney disease. Kidney International 2012, 81: 784-790. PMID: 22258321, PMCID: PMC3319327, DOI: 10.1038/ki.2011.465.Peer-Reviewed Original ResearchMeSH KeywordsAcute-Phase ProteinsAdultAnimalsBiomarkersDisease ProgressionFemaleHumansInterleukin-18KidneyKidney Failure, ChronicLipocalin-2LipocalinsLongitudinal StudiesMaleMiceMice, KnockoutMice, TransgenicOncogene ProteinsPolycystic Kidney, Autosomal DominantProto-Oncogene ProteinsRatsRats, Mutant StrainsRats, Sprague-DawleyReceptors, Interleukin-18TRPP Cation ChannelsConceptsAutosomal dominant polycystic kidney diseaseTotal kidney volumeKidney volumeIL-18Polycystic kidney diseaseKidney diseaseCyst fluidRenal tubular integrityIL-18 levelsRenal Disease equationSerial urine samplesGlomerular filtration rateModification of DietExpression of Lcn2Min/yearPolycystic Kidney Disease (CRISP) studyUrine of patientsDominant polycystic kidney diseaseKidney Disease studyUrinary collecting systemMean percentage increaseSPRD rat modelUrinary NGALUrine NGALKidney injury
2011
Should Living Kidney Donor Candidates with Impaired Fasting Glucose Donate?
Vigneault CB, Asch WS, Dahl NK, Bia MJ. Should Living Kidney Donor Candidates with Impaired Fasting Glucose Donate? Clinical Journal Of The American Society Of Nephrology 2011, 6: 2054-2059. PMID: 21784837, DOI: 10.2215/cjn.03370411.BooksConceptsTransplant centersLiving donorsDonor candidatesGreater riskImpaired glucose toleranceImpaired glucose metabolismDefinition of diabetesPotential living donorsKidney donor candidatesFuture diabetesKidney transplantMetabolic syndromeGlucose toleranceKidney donorsDonor screeningTransplant guidelinesHispanic ethnicityGlucose metabolismDiabetesHispanic individualsPotential donorsIFGRiskDonorsEthnicity
2008
Thrombotic Microangiopathy and Renal Failure Exacerbated by ε-Aminocaproic Acid
Mutter WP, Stillman IE, Dahl NK. Thrombotic Microangiopathy and Renal Failure Exacerbated by ε-Aminocaproic Acid. American Journal Of Kidney Diseases 2008, 53: 346-350. PMID: 18805613, DOI: 10.1053/j.ajkd.2008.07.023.Peer-Reviewed Original Research
2003
Deficient HCO 3 - Transport in an AE1 Mutant with Normal Cl- Transport Can be Rescued by Carbonic Anhydrase II Presented on an Adjacent AE1 Protomer*
Dahl NK, Jiang L, Chernova MN, Stuart-Tilley AK, Shmukler BE, Alper SL. Deficient HCO 3 - Transport in an AE1 Mutant with Normal Cl- Transport Can be Rescued by Carbonic Anhydrase II Presented on an Adjacent AE1 Protomer*. Journal Of Biological Chemistry 2003, 278: 44949-44958. PMID: 12933803, DOI: 10.1074/jbc.m308660200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAnion Exchange Protein 1, ErythrocyteAnionsBicarbonatesBinding SitesBiological TransportCarbonic Anhydrase IIChloridesDimerizationFemaleGene DeletionGene ExpressionHumansLipid BilayersMiceMolecular Sequence DataMutagenesisMutation, MissenseOocytesProtein SubunitsStructure-Activity RelationshipTransfectionXenopusConceptsCl-/HCO3- exchange activityPrevention of Ca2Normal CLCl-/HCO3II inhibitionHCO3- transportIntracellular HCO3Missense mutationsCytoplasmic tailC-terminal cytoplasmic tailXenopus oocytesCa2Binding sitesCl transportAE1InhibitionIntact Ca2Minimal extentCarbonic anhydrase IIActivityMissense mutantsPathwayAE1 mutantsExchange activity