Mice Transgenic for HTLV-I LTR-tax Exhibit Tax Expression in Bone, Skeletal Alterations, and High Bone Turnover
Ruddle N, Li C, Horn W, Santiago P, Troiano N, Jay G, Horowitz M, Baron R. Mice Transgenic for HTLV-I LTR-tax Exhibit Tax Expression in Bone, Skeletal Alterations, and High Bone Turnover. Virology 1993, 197: 196-204. PMID: 8212554, DOI: 10.1006/viro.1993.1580.Peer-Reviewed Original ResearchConceptsHigh bone turnoverHTLV-I infectionBone turnoverMice transgenicSkeletal alterationsAdult T-cell leukemiaMonths of ageSpindle-shaped cellsT-cell leukemiaBone cell activityPaget's diseaseViral etiologyOsteoclast numberBone resorptionPathogenetic mechanismsBone diseaseCell leukemiaBone marrowCell activitySkeletal changesTax mRNASevere skeletal abnormalitiesHost factorsDiseaseSkeletal abnormalitiesProbing the mechanism of TNF-α(cachectin)- and TNF-β(lymphotoxin)-induced pancreatic inflammation with transgenic mice
Ruddle NH, Picarella D, Kratz A, Li C, Flavell RA. Probing the mechanism of TNF-α(cachectin)- and TNF-β(lymphotoxin)-induced pancreatic inflammation with transgenic mice. Research In Immunology 1993, 144: 336-342. PMID: 8278655, DOI: 10.1016/s0923-2494(93)80077-c.Peer-Reviewed Original Research