Mice Transgenic for HTLV-I LTR-tax Exhibit Tax Expression in Bone, Skeletal Alterations, and High Bone Turnover
Ruddle N, Li C, Horn W, Santiago P, Troiano N, Jay G, Horowitz M, Baron R. Mice Transgenic for HTLV-I LTR-tax Exhibit Tax Expression in Bone, Skeletal Alterations, and High Bone Turnover. Virology 1993, 197: 196-204. PMID: 8212554, DOI: 10.1006/viro.1993.1580.Peer-Reviewed Original ResearchConceptsHigh bone turnoverHTLV-I infectionBone turnoverMice transgenicSkeletal alterationsAdult T-cell leukemiaMonths of ageSpindle-shaped cellsT-cell leukemiaBone cell activityPaget's diseaseViral etiologyOsteoclast numberBone resorptionPathogenetic mechanismsBone diseaseCell leukemiaBone marrowCell activitySkeletal changesTax mRNASevere skeletal abnormalitiesHost factorsDiseaseSkeletal abnormalitiesThe lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-κB in human T-cell lines
Paul N, Millet I, Ruddle N. The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-κB in human T-cell lines. Cytokine 1993, 5: 372-378. PMID: 7505113, DOI: 10.1016/1043-4666(93)90070-l.Peer-Reviewed Original Research1-Methyl-3-isobutylxanthineBase SequenceBinding SitesCell LineCell NucleusChloramphenicol O-AcetyltransferaseColforsinCyclic AMPCytotoxicity, ImmunologicGene Products, taxHuman T-lymphotropic virus 1HumansLymphotoxin-alphaMolecular Sequence DataNF-kappa BOligodeoxyribonucleotidesPromoter Regions, GeneticRepetitive Sequences, Nucleic AcidT-LymphocytesTransfectionTumor Cells, Cultured