G protein-coupled receptor kinase 4 gene variants in human essential hypertension
Felder RA, Sanada H, Xu J, Yu PY, Wang Z, Watanabe H, Asico LD, Wang W, Zheng S, Yamaguchi I, Williams SM, Gainer J, Brown NJ, Hazen-Martin D, Wong LJ, Robillard JE, Carey RM, Eisner GM, Jose PA. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 3872-3877. PMID: 11904438, PMCID: PMC122616, DOI: 10.1073/pnas.062694599.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureBody WeightCells, CulturedCHO CellsCricetinaeCyclic AMPFemaleG-Protein-Coupled Receptor Kinase 4Heart RateHeterotrimeric GTP-Binding ProteinsHumansHypertensionImmunohistochemistryKidney Function TestsKidney Tubules, ProximalMaleMiceMice, TransgenicOrgan SizePolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Dopamine D1Signal TransductionConceptsHuman essential hypertensionEssential hypertensionGenetic hypertensionProximal tubulesG-protein-coupled receptor kinase activityEnzyme complexUrinary sodium excretionRenal dopaminergic systemG protein-coupled receptor kinasesProtein-coupled receptor kinasesWild-type geneAbility of dopamineRenal proximal tubulesReceptor kinase activitySodium excretionDopaminergic actionsHypotensive effectChinese hamster ovary cellsDopamine receptorsDopaminergic systemHypertensionLike agonistsElectrolyte balanceTransgenic miceHamster ovary cells