Adipose Tissue in Persons With HIV Is Enriched for CD4+ T Effector Memory and T Effector Memory RA+ Cells, Which Show Higher CD69 Expression and CD57, CX3CR1, GPR56 Co-expression With Increasing Glucose Intolerance
Wanjalla CN, McDonnell WJ, Barnett L, Simmons JD, Furch BD, Lima MC, Woodward BO, Fan R, Fei Y, Baker PG, Ram R, Pilkinton MA, Mashayekhi M, Brown NJ, Mallal SA, Kalams SA, Koethe JR. Adipose Tissue in Persons With HIV Is Enriched for CD4+ T Effector Memory and T Effector Memory RA+ Cells, Which Show Higher CD69 Expression and CD57, CX3CR1, GPR56 Co-expression With Increasing Glucose Intolerance. Frontiers In Immunology 2019, 10: 408. PMID: 30941121, PMCID: PMC6433850, DOI: 10.3389/fimmu.2019.00408.Peer-Reviewed Original ResearchConceptsHIV-negative controlsSubcutaneous adipose tissueT effector memoryAdipose tissueMemory CD45ROEffector memoryGlucose intoleranceMemory subsetsT cellsChronic T cell activationProgressive glucose intoleranceAdipose tissue inflammationT cell profileDistribution of CD4T cell expressionHigher CD69 expressionSimilar glucose toleranceT cell activationWhole adipose tissueCD4 ratioHIV infectionImmune senescenceGlucose toleranceHIV statusCardiometabolic diseases