Inhaled Insulin Is Associated with Prolonged Enhancement of Glucose Disposal in Muscle and Liver in the Canine
Edgerton DS, Cherrington AD, Neal DW, Scott M, Lautz M, Brown N, Petro J, Hobbs CH, Leach C, Del Parigi A, Strack TR. Inhaled Insulin Is Associated with Prolonged Enhancement of Glucose Disposal in Muscle and Liver in the Canine. Journal Of Pharmacology And Experimental Therapeutics 2008, 328: 970-975. PMID: 19098161, PMCID: PMC3202424, DOI: 10.1124/jpet.108.146985.Peer-Reviewed Original ResearchConceptsInhalation of insulinPlasma glucose levelsGlucose levelsDiabetic patientsGlucose disposalNet hepatic glucose uptakeGlucose uptakeArterial plasma glucose levelsHepatic sinusoidal insulinBasal plasma levelsNonhepatic glucose uptakeGlucose infusion rateHepatic glucose uptakeInhalation groupInsulin inhalationSubcutaneous insulinPeripheral veinPlasma levelsPortal veinPlasma insulin kineticsInsulin secretionInfusion rateInsulin actionGlucose utilizationInhalation