2015
Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.
Krishnan N, Perazella MA. Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment. Iranian Journal Of Kidney Diseases 2015, 9: 3-13. PMID: 25599729.BooksConceptsDrug-induced acute interstitial nephritisCell-mediated immune injuryLess chronic kidney diseaseAcute interstitial nephritisHallmark pathologic featureIncomplete renal recoveryInterstitial dendritic cellsNeo-antigen formationPredominance of CD4Acute kidney injurySerum creatinine levelsChronic kidney diseaseMainstay of treatmentRenal tubular epithelial cellsUse of steroidsDuration of injuryTubular epithelial cellsRenal recoveryChronic dialysisKidney injuryCreatinine levelsImmunologic injuryInterstitial inflammationDendritic cellsImmune injury
2008
A Mutation in the Mouse Chd2 Chromatin Remodeling Enzyme Results in a Complex Renal Phenotype
Marfella CG, Henninger N, LeBlanc SE, Krishnan N, Garlick DS, Holzman LB, Imbalzano AN. A Mutation in the Mouse Chd2 Chromatin Remodeling Enzyme Results in a Complex Renal Phenotype. Kidney & Blood Pressure Research 2008, 31: 421-432. PMID: 19142019, PMCID: PMC2818461, DOI: 10.1159/000190788.Peer-Reviewed Original ResearchConceptsChd2 proteinATP-dependent chromatin remodelingChromodomain helicase DNA-binding protein 2DNA-binding protein 2Family of enzymesChromatin remodelingChromatin structureEpigenetic regulatorsGlomerular diseaseGene expressionMolecular mechanismsKidney functionProtein 2Enzyme resultsDiverse groupProteinNew insightsMutationsRenal phenotypeKidney failureGlomerular functionHematocrit levelsNew moleculesSerum analysisMice