2016
Efficacy and Safety of Nonopioid Analgesics in Perioperative Pain Control.
Thomas DA, West M, Legler A, Maslin B, Kim RK, Vadivelu N. Efficacy and Safety of Nonopioid Analgesics in Perioperative Pain Control. Current Drug Safety 2016, 11: 196-205. PMID: 27113953, DOI: 10.2174/1574886311666160426130444.Peer-Reviewed Original ResearchConceptsPain controlNonopioid analgesicsSide effectsContemporary pain managementOptimum pain controlPerioperative pain controlAcute postoperative painPostoperative pain controlMultiple side effectsNonopioid medicationsPostoperative painTolerant patientsPain managementSafety profileAnalgesicsRecent dataComorbiditiesMedicationsOpioidsPainPatientsSurgeryMainstayControl
2012
Postoperative apnea, respiratory strategies, and pathogenesis mechanisms: a review
Kaye AD, Hollon MM, Vadivelu N, Kodumudi G, Kaye RJ, Bueno FR, Baluch AR. Postoperative apnea, respiratory strategies, and pathogenesis mechanisms: a review. Journal Of Anesthesia 2012, 27: 423-432. PMID: 23179739, DOI: 10.1007/s00540-012-1517-0.Peer-Reviewed Original ResearchConceptsPostoperative apneaPostoperative patientsPostoperative pulmonary complicationsTerms of mortalityPostoperative ventilationPulmonary complicationsHospital staySupportive careVentilation supportAirway maintenanceCerebral cortexAdequate oxygenationAortic bodiesDifferential diagnosisApneaPathogenesis mechanismsOxygenationPatientsRespiratory strategiesVentilationAdditional oxygenationPhysiological mechanismsCauseExtubationMorbidity
2011
Peripheral opioid receptor agonists for analgesia: a comprehensive review.
Vadivelu N, Mitra S, Hines RL. Peripheral opioid receptor agonists for analgesia: a comprehensive review. Journal Of Opioid Management 2011, 7: 55-68. PMID: 21434585, DOI: 10.5055/jom.2011.0049.Peer-Reviewed Original ResearchConceptsPeripheral opioid receptorsOpioid receptor agonistsOpioid receptorsReceptor agonistOpioid analgesiaPeripheral opioid receptor agonistDelta-opioid receptor agonistPhase I clinical trialPeripheral opioid agonistPeripheral opioid analgesiaDorsal root gangliaObvious theoretical advantagesOpioid agonist activityPeripheral muAfferent nervesAfferent neuronsOpioid analgesicsPeripheral terminalsCentral actionOpioid agonistsAntidiarrheal drugsOpioidergic systemRoot gangliaClinical trialsPeripheral tissues
2007
Buprenorphine: a unique opioid with broad clinical applications.
Vadivelu N, Hines RL. Buprenorphine: a unique opioid with broad clinical applications. Journal Of Opioid Management 2007, 3: 49-58. PMID: 17367094, DOI: 10.5055/jom.2007.0038.Peer-Reviewed Original ResearchConceptsAnti-inflammatory agentsPartial mu agonistRoute of administrationUnique opioidPerioperative painAdequate analgesiaAnalgesic potentialMu agonistsBroad clinical applicationOpioid addictionAddictive potentialClinical applicationBuprenorphineAgonistsPositive resultsAnalgesiaMedicationsOpioidsPainAdministration