Perioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone.
Kaye AD, Alian AA, Vadivelu N, Chung KS. Perioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone. Journal Of Opioid Management 2014, 10: 69-72. PMID: 24604572, DOI: 10.5055/jom.2014.0194.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaHigh dosesHigh-dose opioidsCancer-related painPresent case reportMega dosesOpioid requirementsOpioid managementMetastatic leiomyosarcomaAgonist clonidineCase reportPotent analgesicOpioidsPatientsSuccessful managementDosesPainMethadoneMorphineHyperalgesiaClonidineAnalgesicsLeiomyosarcomaManagementAntagonist