Chromosomal Aberrations and Exon 1 Mutation in the AKR1B1 Gene in Patients with Diabetic Neuropathy.
Saraswathy R, Anand S, Kunnumpurath SK, Kurian RJ, Kaye AD, Vadivelu N. Chromosomal Aberrations and Exon 1 Mutation in the AKR1B1 Gene in Patients with Diabetic Neuropathy. Ochsner Journal 2014, 14: 339-42. PMID: 25249799, PMCID: PMC4171791.Peer-Reviewed Original ResearchType 2 diabetes mellitusPainful diabetic neuropathyDiabetic neuropathyAKR1B1 geneDiabetes mellitusChromosomal aberrationsNeuropathic pathogenesisTremendous morbidityDM patientsTreatment optionsNeuropathyOxidative DNA damageExon 1 mutationsPatientsControl groupPathophysiological processesCultured lymphocytesPatient samplesChromosomal damagePilot investigationHigh rateSignificant mutationsPossible mutationsDNA damageSignificant number