2016
Perioperative Safety of Warfarin Therapy and Reversal.
Maslin B, Springer E, Zhu R, Kodumudi V, Vadivelu N. Perioperative Safety of Warfarin Therapy and Reversal. Current Drug Safety 2016, 11: 149-55. PMID: 26674352, DOI: 10.2174/1574886311666151217121553.Peer-Reviewed Original ResearchConceptsWarfarin therapyEmergent surgeryPatient groupMultidisciplinary consensus guidelinesRisk stratification algorithmCertain patient groupsVulnerable patient groupRegional anesthetic techniquesClinical decision pointsUnited States populationThromboembolic consequencesPerioperative periodPerioperative safetyBlood lossPerioperative careProcedural complicationsClinical outcomesPreoperative patientsAnesthetic techniqueRetrospective studyConsensus guidelinesPerioperative cliniciansClinical trialsCoordinated careClinical studies
2015
Effects of Anesthetic Management on Early Postoperative Recovery, Hemodynamics and Pain After Supratentorial Craniotomy
Ayrian E, Kaye AD, Varner CL, Guerra C, Vadivelu N, Urman RD, Zelman V, Lumb PD, Rosa G, Bilotta F. Effects of Anesthetic Management on Early Postoperative Recovery, Hemodynamics and Pain After Supratentorial Craniotomy. Journal Of Clinical Medicine Research 2015, 7: 731-741. PMID: 26345202, PMCID: PMC4554211, DOI: 10.14740/jocmr2256w.Peer-Reviewed Original ResearchSupratentorial craniotomyIntracranial pressureInhalational anestheticsIntravenous anestheticsCognitive recoveryEarly postoperative recoveryAddition of corticosteroidsTotal intravenous anesthesiaElevated intracranial pressureNormal intracranial pressureComparison of opioidCOX-2 inhibitorsSuperior analgesiaExtubation timeAnesthetic managementPostoperative recoveryIntraoperative anestheticsIntravenous anesthesiaPCa therapyClinical trialsAnesthetic choiceEarly recoveryLocal anestheticsLong-term effectsDifferent anesthetics
2013
Patient considerations in the use of tapentadol for moderate to severe pain
Vadivelu N, Huang Y, Mirante B, Jacoby M, Braveman FR, Hines RL, Sinatra R. Patient considerations in the use of tapentadol for moderate to severe pain. Drug Healthcare And Patient Safety 2013, Volume 5: 151-159. PMID: 23861601, PMCID: PMC3704302, DOI: 10.2147/dhps.s28829.Peer-Reviewed Original ResearchTapentadol ERTapentadol IRSevere painChronic painOpioid agonistsClinical trialsSide effectsChronic painful diabetic neuropathyMu-opioid receptor agonistCentral nervous system depressantsSimilar pain reliefTraditional opioid agonistsUncontrolled postoperative painSevere acute painSevere chronic painGastrointestinal adverse effectsPainful diabetic neuropathyCommon side effectsNorepinephrine reuptake inhibitorsPost-surgical patientsOpioid receptor agonistsUse of tapentadolDrug Administration approvalMonoamine oxidase inhibitorsPotent opioid agonist
2011
Peripheral opioid receptor agonists for analgesia: a comprehensive review.
Vadivelu N, Mitra S, Hines RL. Peripheral opioid receptor agonists for analgesia: a comprehensive review. Journal Of Opioid Management 2011, 7: 55-68. PMID: 21434585, DOI: 10.5055/jom.2011.0049.Peer-Reviewed Original ResearchConceptsPeripheral opioid receptorsOpioid receptor agonistsOpioid receptorsReceptor agonistOpioid analgesiaPeripheral opioid receptor agonistDelta-opioid receptor agonistPhase I clinical trialPeripheral opioid agonistPeripheral opioid analgesiaDorsal root gangliaObvious theoretical advantagesOpioid agonist activityPeripheral muAfferent nervesAfferent neuronsOpioid analgesicsPeripheral terminalsCentral actionOpioid agonistsAntidiarrheal drugsOpioidergic systemRoot gangliaClinical trialsPeripheral tissues